Effect of Nitrous Oxide on Aggression.

Description

The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive tendencies. The main question aims to answer are: Does Nitrous Oxide normalize brain circuit function in impulsively aggressive individuals 24 hours after inhalation. Participants will undergo a 60 minute inhalation session with 50% Nitrous Oxide (or room air at another session) and then undergo an fMRI scan 24 hours later. Researchers will compare healthy controls and impulsively aggressive individuals to see if Nitrous Oxide can normalize the function of cortico-limbic circuits in the latter group.

Conditions

Intermittent Explosive Disorder

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Study Overview

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Study Details

Study overview

The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive tendencies. The main question aims to answer are: Does Nitrous Oxide normalize brain circuit function in impulsively aggressive individuals 24 hours after inhalation. Participants will undergo a 60 minute inhalation session with 50% Nitrous Oxide (or room air at another session) and then undergo an fMRI scan 24 hours later. Researchers will compare healthy controls and impulsively aggressive individuals to see if Nitrous Oxide can normalize the function of cortico-limbic circuits in the latter group.

Nitrous Oxide and Cortico-Limbic Function in Aggression

Effect of Nitrous Oxide on Aggression.

Condition
Intermittent Explosive Disorder
Intervention / Treatment

-

Contacts and Locations

Columbus

Ohio State University Wexner Medical Center, Columbus, Ohio, United States, 43210

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Between 21 and 55 years of age.
  • * Physically healthy (no clinically significant medical condition as confirmed by medical history/physical exam).
  • * Able to give informed consent.
  • * Current DSM-5 Criteria for IED
  • * LHA Aggression scores \> 12
  • * Negative for a history of psychosis, bipolar disorder, developmental disorder, intellectual disability or a current substance use disorder.
  • * Do not meet current/lifetime DSM-5 Criteria for any psychiatric disorder
  • * LHA aggression scores \< 12
  • * PCL Screening Version Score \> 13; i.e., subject is likely to be psychopathic.32
  • * Current DSM-5 Major Depressive Episode.
  • * Life history of bipolar disorder/schizophrenia/organic mental syndrome.
  • * Intellectual disability \[i.e., IQ \< 70\].
  • * History of N2O abuse/dependence.
  • * Clinically significant medical condition.
  • * Current alcohol/drug use disorder of moderate or severe severity (i.e., subject is not in full remission from moderate to severe alcohol/drug use).
  • * Two weeks free of antipsychotic medication. (Note: Because a large number of individuals with aggressive tendencies in the community are already taking SSRIs, SNRIs, or mood stabilizers, these individuals will not be excluded if they continue to report impulsive aggressive behaviors at time of study.)
  • * Unwilling/unable to sign informed consent document.

Ages Eligible for Study

21 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ohio State University,

Emil Coccaro, M.D., PRINCIPAL_INVESTIGATOR, The Ohio State University Wexner Medical Center

Study Record Dates

2025-08-31