Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Description

The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).

Conditions

Heart Failure

Study Overview

Study Details

Study overview

The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).

A Phase 2A, Double-blind, Randomized, Placebo-controlled, Multi-center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Condition
Heart Failure
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35233

Miami

Infinite Clinical Research, Miami, Florida, United States, 33133-4223

Atlanta

Local Institution - 0014, Atlanta, Georgia, United States, 30322-1013

Atlanta

Local Institution - 0048, Atlanta, Georgia, United States, 30322-1013

Chicago

Bluhm Cardiovascular Institute of Northwestern, Chicago, Illinois, United States, 60611-5969

Hazel Crest

Chicago Medical Research, LLC, Hazel Crest, Illinois, United States, 60429-2196

Indianapolis

Ascension Medical Group St. Vincent - Indianapolis Heart Care, Indianapolis, Indiana, United States, 46260-1992

Indianapolis

Local Institution - 0045, Indianapolis, Indiana, United States, 46260-1992

Saint Louis

St. Louis Heart and Vascular, Saint Louis, Missouri, United States, 63136-6111

Saint Louis

Local Institution - 0043, Saint Louis, Missouri, United States, 63136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    40 Years to 90 Years

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Bristol-Myers Squibb,

    Bristol-Myers Squibb, STUDY_DIRECTOR, Bristol-Myers Squibb

    Study Record Dates

    2026-07-03