Androgens and NAFLD Longitudinal Cohort Study

Description

The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can cause damage to the liver such as inflammation or scarring. Young women with a condition called polycystic ovary syndrome (PCOS) have a high risk for NAFLD, and they often have high androgen levels too. So the researchers are recruiting young women with PCOS as well as those without PCOS, and will compare changes in NAFLD over time between young women with and without PCOS. This study is funded by the National Institutes of Health

Conditions

PCOS, NAFLD, NASH

Study Overview

Study Details

Study overview

The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can cause damage to the liver such as inflammation or scarring. Young women with a condition called polycystic ovary syndrome (PCOS) have a high risk for NAFLD, and they often have high androgen levels too. So the researchers are recruiting young women with PCOS as well as those without PCOS, and will compare changes in NAFLD over time between young women with and without PCOS. This study is funded by the National Institutes of Health

Androgens and Nonalcoholic Fatty Liver Disease (NAFLD) In Reproductive-Aged Women With and Without Polycystic Ovary Syndrome (PCOS)

Androgens and NAFLD Longitudinal Cohort Study

Condition
PCOS
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California San Francisco, San Francisco, California, United States, 94143

Durham

Duke University, Durham, North Carolina, United States, 27708

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Metabolic associated steatohepatitis (MASH) (formerly NASH)
  • * PCOS
  • * Non-PCOS
  • * High levels of alcohol use (more than 7 drinks a week)
  • * Current pregnancy
  • * Other causes of hepatic steatosis
  • * Weight loss of more than 10% body weight in the last 6 months

Ages Eligible for Study

18 Years to 42 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Monika A Sarkar, M.D., M.A.S, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Ayako Suzuki, M.D.,Ph.D., PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2028-12