RECRUITING

Androgens and NAFLD Longitudinal Cohort Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can cause damage to the liver such as inflammation or scarring. Young women with a condition called polycystic ovary syndrome (PCOS) have a high risk for NAFLD, and they often have high androgen levels too. So the researchers are recruiting young women with PCOS as well as those without PCOS, and will compare changes in NAFLD over time between young women with and without PCOS. This study is funded by the National Institutes of Health

Official Title

Androgens and Nonalcoholic Fatty Liver Disease (NAFLD) In Reproductive-Aged Women With and Without Polycystic Ovary Syndrome (PCOS)

Quick Facts

Study Start:2024-01-22
Study Completion:2028-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06124261

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 42 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Metabolic associated steatohepatitis (MASH) (formerly NASH)
  2. * PCOS
  3. * Non-PCOS
  1. * High levels of alcohol use (more than 7 drinks a week)
  2. * Current pregnancy
  3. * Other causes of hepatic steatosis
  4. * Weight loss of more than 10% body weight in the last 6 months

Contacts and Locations

Study Contact

Elle K Oberweis-Manion, B.A.
CONTACT
415-502-3725
elle.oberweismanion@ucsf.edu

Principal Investigator

Monika A Sarkar, M.D., M.A.S
PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Ayako Suzuki, M.D.,Ph.D.
PRINCIPAL_INVESTIGATOR
Duke University

Study Locations (Sites)

University of California San Francisco
San Francisco, California, 94143
United States
Duke University
Durham, North Carolina, 27708
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Monika A Sarkar, M.D., M.A.S, PRINCIPAL_INVESTIGATOR, University of California, San Francisco
  • Ayako Suzuki, M.D.,Ph.D., PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-22
Study Completion Date2028-12

Study Record Updates

Study Start Date2024-01-22
Study Completion Date2028-12

Terms related to this study

Keywords Provided by Researchers

  • Androgen

Additional Relevant MeSH Terms

  • PCOS
  • NAFLD
  • NASH