Comparing Endoscopic Ultrasound vs Surgical Gastrojejunostomy for Management of GOO.

Description

The goal of this interventional study is to learn about the outcomes between two options for the management of malignant gastric outlet obstruction.

Conditions

Malignant Gastric Outlet Obstruction

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Study Overview

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Study Details

Study overview

The goal of this interventional study is to learn about the outcomes between two options for the management of malignant gastric outlet obstruction.

A Randomized Trial Comparing Endoscopic UltraSound-guided GasTrojejunostomy (EUS-GJ) and Surgical GastrojejunOstomy (S-GJ) for the Management of Malignant gastRic outlEt Obstruction

Comparing Endoscopic Ultrasound vs Surgical Gastrojejunostomy for Management of GOO.

Condition
Malignant Gastric Outlet Obstruction
Intervention / Treatment

-

Contacts and Locations

Orlando

AdventHealth Orlando, Orlando, Florida, United States, 32804

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. ≥ 18 years of age.
  • 2. Radiographic OR Endoscopic evidence of an obstructing neoplasm in the distal stomach or duodenum.
  • 3. GOOSS of 0 or 1
  • 4. BOTH surgical and endoscopic GJ are technically and clinically feasible
  • 5. Can understand and is willing to sign informed consent form prior to the initiation of any study procedures (or when applicable the subject's LAR).
  • 1. \< 18 years of age
  • 2. ECOG \>2
  • 3. Expected survival (determined by the treating oncologist) is less than 2 months.
  • 4. Candidates for potential resection of the cancer and obstructed anatomical area (this includes patients with borderline resectable pancreatic cancer)
  • 5. Peritoneal carcinomatosis with associated bowel obstruction on imaging or during laparoscopy
  • 6. Large volume ascites (patients with moderate volume ascites may undergo IR guided drainage prior to randomization)
  • 7. Anatomical factors that technically hinder EUS-GJ OR Surgical-GJ (diffuse tumor involvement in path of LAMS or surgery, surgically altered anatomy that interferes with the ability to perform an anastomosis etc)
  • 8. Pregnancy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

AdventHealth,

Kambiz Kadkhodayan, MD, PRINCIPAL_INVESTIGATOR, AdventHealth

Study Record Dates

2026-07-31