Comparison of Procedural Sedation in TEE

Description

The objective of this proposal is to conduct a prospective randomized study comparing the utility of sedating patients undergoing transesophageal echocardiographic studies with a novel, recently-FDA-approved sedative agent, remimazolam, versus the sedative used in our current practice at UAB, propofol. This study will investigate whether remimazolam offers any benefit over current care vis-à-vis hemodynamics or efficiency/throughput. This study will be conducted at the University of Alabama at Birmingham. All outpatients and inpatients scheduled for elective/non-emergent TEE in the UAB Heart and Vascular Center TEE lab will be considered for enrollment.

Conditions

Anesthesia

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Study Overview

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Study Details

Study overview

The objective of this proposal is to conduct a prospective randomized study comparing the utility of sedating patients undergoing transesophageal echocardiographic studies with a novel, recently-FDA-approved sedative agent, remimazolam, versus the sedative used in our current practice at UAB, propofol. This study will investigate whether remimazolam offers any benefit over current care vis-à-vis hemodynamics or efficiency/throughput. This study will be conducted at the University of Alabama at Birmingham. All outpatients and inpatients scheduled for elective/non-emergent TEE in the UAB Heart and Vascular Center TEE lab will be considered for enrollment.

Comparison of Remimazolam with Propofol for Procedural Sedation in TEE

Comparison of Procedural Sedation in TEE

Condition
Anesthesia
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham Hospital, Birmingham, Alabama, United States, 35233

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Inpatients and outpatients \>=18 years who are scheduled to undergo elective/non-emergent transesophageal echocardiography at the UAB Heart and Vascular Center TEE Lab.
  • * Patients undergoing emergent TEE procedure in the HVC TEE Lab.
  • * Patients undergoing elective or emergent TEE procedure in the ICU and/or at the patient bedside.
  • * Patients undergoing elective or emergent TEE procedure in a location other than HVC TEE Lab.
  • * Patients undergoing an additional procedure or surgery (before or after TEE) as part of the same anesthetic, except for DC Cardioversion.
  • * Children under the age of 19 years (or under 50 kg body weight if age is unknown).
  • * Pregnant patients.
  • * Breastfeeding/nursing patients.
  • * Incarcerated patients.
  • * Patients enrolled in a concurrent ongoing interventional randomized clinical trial.

Ages Eligible for Study

18 Years to 89 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Alabama at Birmingham,

Study Record Dates

2026-03