Effect of Ketamine on Intraoperative Motor Evoked Potentials

Description

The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic. In addition to the standard anesthetic, the patients will be administered increasing doses of ketamine with motor-evoked potentials being measured at each dose, to assess any impacts.

Conditions

Spine Fusion, Spine Tumor, Spinal Stenosis

Study Overview

Study Details

Study overview

The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic. In addition to the standard anesthetic, the patients will be administered increasing doses of ketamine with motor-evoked potentials being measured at each dose, to assess any impacts.

Effect of Ketamine on Intraoperative Motor Evoked Potentials

Effect of Ketamine on Intraoperative Motor Evoked Potentials

Condition
Spine Fusion
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patients (\>18 years of age) undergoing posterior spinal fusions.
  • * Sensitivity or allergy to ketamine.
  • * Schizophrenia or other psychotic conditions
  • * Uncontrolled hypertension with systolic blood pressure greater than 180 mmHg
  • * Myocardial Infarction
  • * Large vascular aneurysms
  • * Patients on ketamine as outpatient therapy.

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Marc Buren, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2026-12-01