Transcranial Magnetic Stimulation (TMS) to Treat Depression in Autism Spectrum Disorder

Eligibility Criteria

• * Individuals from Yale University and the surrounding community who are between the ages of 18 and 40 years old with or without a diagnosis of depression. Or individuals between the ages of 18 and 40 years old with a diagnosis of autism spectrum disorder, autistic disorder, PDD NOS, or Asperger syndrome with or without a diagnosis of depression.
• * A depression score on the HDRS-17 of at least 20 will be used as a cut-off for depression.
• * Participants are unmedicated or on stable medication treatment for at least two weeks.
• * Willingness and ability to participate in an EEG and eye-tracking procedure.
• * Provision of signed and dated informed consent.
• * Participants reporting significant head trauma or serious brain illness.
• * Participants unable to provide signed informed consent.
• * Participants with major psychiatric illness that would preclude completion of study measures. Participants with diagnosis of a psychotic or bipolar illness with be excluded.
• * Participants with a history of serious medical illness, stroke, seizures, epileptiform EEG abnormalities, or family history of epilepsy.
• * Participants taking prescription medications that may affect cognitive processes under study.
• * Participants taking any medication that may increase their risk of seizures.
• * Participants who have taken alcohol or recreational drugs within the preceding 24 hours prior to the scheduled study visit as determined by the urine toxicology test.
• * Participants with a history of substance or alcohol abuse or dependence in the past 6 months.
• * Participants with a significant risk of suicide or a h/o suicide attempt in the last 6 months. Participants with active suicidal ideation will be excluded from the study.
• * Females of known/suspected pregnancy or who test positive on a pregnancy test.
• * Participants with a history of metalworking or injury by shrapnel or metallic objects.
• * Participants with a history of prior TMS therapy or use of an investigational drug within 12 weeks of visit
• * Participants with an IQ below 80 (as confirmed by the WASI, Wechsler Abbreviated Scale of Intelligence)