Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement

Description

The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.

Conditions

Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization

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Study Overview

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Study Details

Study overview

The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.

Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement

Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement

Condition
Edentulous Mouth
Intervention / Treatment

-

Contacts and Locations

Cleveland

Case Western Reserve University Department of Periodontics, Cleveland, Ohio, United States, 44106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. At least 21 years of age
  • 2. Diagnosis of Stage III or IV periodontitis based on full mouth probing and full mouth x-rays
  • 3. Planned for full mouth extraction and replacement by dental implants.
  • 4. Rehabilitation with Implant supported restorations either maxilla and/ or mandible.
  • 5. At least 2 implants available for examination.
  • 6. No bone augmentation required.
  • 1. Conditions requiring chronic routine prophylactic use of antibiotics.
  • 2. Conditions requiring prolonged use of steroids.
  • 3. History of leukocyte dysfunction and deficiencies
  • 4. Bleeding disorders
  • 5. History of neoplastic disease requiring use of radiation or chemotherapy
  • 6. Metabolic bone disorders
  • 7. Uncontrolled endocrine disorder
  • 8. Use of any investigational drug or device within the 30 day period prior to implant surgery.
  • 10. Alcoholism or drug abuse 11. Patient infected with HIV 12. Condition or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, unreliability.
  • 1. Local inflammation
  • 2. Mucosal disease such as erosive lichen planus
  • 3. History of local irradiation therapy
  • 4. Osseous lesion.
  • 5. Active infection with suppuration or fistula track.
  • 6. Persistent intraoral infection different than periodontitis

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Case Western Reserve University,

Gian Pietro Schincaglia, DDS,PhD, PRINCIPAL_INVESTIGATOR, Case Western Reserve University

Study Record Dates

2026-05-01