A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

Description

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

Conditions

Coarctation of Aorta, High Blood Pressure

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Study Overview

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Study Details

Study overview

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

A Phase III, Randomized, Double-Blind, Placebo Controlled Clinical Trial Evaluating the Benefits and Mechanism Of Action Of Angiotensin-II Receptor Blocker On Cardiovascular Remodeling In Patients With Repaired Coarctation Of Aorta

A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

Condition
Coarctation of Aorta
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * B/S1 hypertension
  • * SBP 100-139 average based on 3 office measurements.
  • * Age 18 or Older
  • * Previous COA Repair
  • * Currently on beta blocker (BB) therapy
  • * Pregnancy/lactating
  • * eGFR\<30
  • * Hyperkalemia (serum potassium \>5.5mmol/L)
  • * Severe Aortic or Mitral valve stenosis or regurgitation
  • * Epicardial CAD diagnosis
  • * Received antihypertensive medications within the past year

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Alexander Egbe, MBBS, MPH, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2028-06-01