Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

Description

In this exploratory study, the hormonal responses to a mixed meal will be examined in people with cystic fibrosis. The aim of this study is to find correlates with impaired glucose tolerance that is associated with this population.

Conditions

Cystic Fibrosis

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Study Overview

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Study Details

Study overview

In this exploratory study, the hormonal responses to a mixed meal will be examined in people with cystic fibrosis. The aim of this study is to find correlates with impaired glucose tolerance that is associated with this population.

Changes in Postprandial Hormone Levels in Cystic Fibrosis Related Diabetes.

Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

Condition
Cystic Fibrosis
Intervention / Treatment

-

Contacts and Locations

Cincinnati

University of Cincinnati, Cincinnati, Ohio, United States, 45267-0547

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosed with cystic fibrosis
  • * Aged 18 to 45 years
  • * Males and females of any race and ethnicity
  • * Receiving highly effective CFTR modular therapy
  • * Transplant recipient
  • * Acute lung function decline or exacerbation within the last 3 months
  • * Use of systemic glucocorticoids
  • * Pregnancy
  • * Known liver disease that would be expected to significantly impact metabolic variable as interpreted by a study doctor
  • * The presence of any other disease or condition, as interpreted by any one of the study doctors, that would be expected to confound the responses to liquid mixed meal or make participation in the study dangerous to the individual
  • * People who are cognitively impaired
  • * People who do not speak English
  • * For CFRD patients, a daily insulin requirement that exceeds 0.8 U/kg/day
  • * Any prior history of diabetic ketoacidosis.

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Cincinnati,

Jason Winnick, PhD, PRINCIPAL_INVESTIGATOR, University of Cincinnati

Study Record Dates

2025-12-31