Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)

Description

The purpose of this study is to determine the relationship between the levels of Ribonucleic acid (RNA) circulating molecules, including ones in extracellular vesicles from different organs in the blood and in the saliva of patients with Acute Decompensated Heart Failure (ADHF) and Chronic Heart Failure (CHF) to see if a new, non-invasive diagnostic test can be developed for heart failure exacerbation.

Conditions

CHF, ADHF, Control

Study Overview

Study Details

Study overview

The purpose of this study is to determine the relationship between the levels of Ribonucleic acid (RNA) circulating molecules, including ones in extracellular vesicles from different organs in the blood and in the saliva of patients with Acute Decompensated Heart Failure (ADHF) and Chronic Heart Failure (CHF) to see if a new, non-invasive diagnostic test can be developed for heart failure exacerbation.

Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)

Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)

Condition
CHF
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Active pregnancy or lactation
  • * Cardiac amyloidosis
  • * Active malignancies

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Massachusetts General Hospital,

Saumya Das, MD, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Michail Spanos, MD, STUDY_DIRECTOR, Massachusetts General Hospital

Study Record Dates

2025-12-31