Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

Description

To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent larger efficacy trial.

Conditions

Age-related Cerebral White Matter Changes, Cognition Disorder

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Study Overview

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Study Details

Study overview

To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent larger efficacy trial.

Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

Condition
Age-related Cerebral White Matter Changes
Intervention / Treatment

-

Contacts and Locations

Augusta

Wellstar MCG Health, Augusta, Georgia, United States, 30912

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age ≥55 years
  • 2. Head MRI in the past 6 months showing no more than moderate age related cerebral white matter changes (Fazekas score 0-2).
  • 3. Able to walk without assistance \& independently perform basic activities of daily living.
  • 4. Able to understand this study and agree for a valid consent.
  • 4. Contraindication to transient arm ischemia in either arm (such as symptomatic peripheral artery disease).

Ages Eligible for Study

56 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Augusta University,

Carol Smith, RN, STUDY_DIRECTOR, Wellstar MCG Health

Study Record Dates

2023-12-15