Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy

Description

This purpose of this study is to examine skin reactions (called radiation dermatitis) that occur during pencil beam scanning (PBS) proton therapy. The researchers will test a unique technique called "Spot Delete" to see if it can reduce skin reactions for head \& neck patients treated with PBS. The investigators will also use a special computer model to study how the energy of the proton beam (linear energy transfer) is related to these skin reactions. The study involves creating a treatment plan based on a CT scan, which helps guide the proton beam in the body.

Conditions

Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Head and Neck Carcinoma

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Study Overview

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Study Details

Study overview

This purpose of this study is to examine skin reactions (called radiation dermatitis) that occur during pencil beam scanning (PBS) proton therapy. The researchers will test a unique technique called "Spot Delete" to see if it can reduce skin reactions for head \& neck patients treated with PBS. The investigators will also use a special computer model to study how the energy of the proton beam (linear energy transfer) is related to these skin reactions. The study involves creating a treatment plan based on a CT scan, which helps guide the proton beam in the body.

Evaluation of Radiobiological Effects in Skin Toxicities for Head and Neck Cancer Patients With Pencil Beam Scanning Proton Therapy

Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy

Condition
Head and Neck Cancer
Intervention / Treatment

-

Contacts and Locations

Knoxville

Thompson Proton Center, Knoxville, Tennessee, United States, 37909

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * The patient must consent to be in the study and must have signed an approved consent form conforming to federal and institutional guidelines.
  • * Patients must be ≥ 18 years old.
  • * Patient must have biopsy-proven squamous cell carcinoma, originating in the oral cavity, larynx, oropharynx, nasopharynx, or hypopharynx
  • * Carcinoma of the neck of unknown primary site origin may be included if p16 positive
  • * Clinical stage T1-2, N0-1, N2a-N3 or T3-4, any N (AJCC, 7th ed.), including no distant metastases
  • * Patient can have prior surgical resection of a primary cancer in the head and neck at any previous time
  • * Previous or concurrent chemotherapy is allowed
  • * No serious health conditions as determined by physician that would impact ability to complete treatment or impact skin in the area of treatment
  • * Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
  • * Head and neck radiotherapy that does NOT include at least one cervical lymph node level (I, II, III, IV, or V) in the target volume.
  • * Children
  • * Women who are pregnant.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Thompson Cancer Survival Center,

Samantha Hedrick, PhD, DABR, PRINCIPAL_INVESTIGATOR, Thompson Proton Center, Director of Medical Physics

Study Record Dates

2030-01-02