ASHBY: Accelerated Super-Hypofractionated Breast Brachytherapy

Eligibility Criteria

• * Female
• * New diagnosis of ductal carcinoma in situ (DCIS) and/or invasive breast carcinoma per histologic evaluation
• * Age 45-79 at diagnosis
• * Previous lumpectomy with surgical margins histologically free of invasive tumor and DCIS as determined by the pathologist.
• * T stage of Tis, T1, or T2.
• * T2 tumors must be ≤3 cm in maximum diameter
• * If the tumor is human epidermal growth factor receptor 2 (HER2)-positive, the patient must receive HER2-directed therapy.
• * For patients with invasive breast cancer, an axillary staging procedure must be performed (either sentinel node biopsy alone or axillary dissection \[with a minimum of 6 axillary nodes removed\]) and the axillary node\[s\] must be pathologically negative.
• * Note: N0(i+) is not an exclusion criterion.
• * Note: Patients meeting all of the following criteria are not required to undergo the axillary staging procedure:
• * ≥70 years of age
• * estrogen receptor, Her2 = human epidermal growth factor receptor 2, PR = progesterone receptor negative (ER+PR+HER2-)
• * G1-2
• * Tumor ≤2 cm in size
• * Agrees to comply with aromatase inhibitor recommendation
• * Ability to understand and the willingness to sign a written informed consent document in English
• * Pregnant or breastfeeding
• * Active collagen-vascular disease
• * Paget's disease of the breast
• * History of DCIS or invasive breast cancer prior to the current diagnosis
• * Prior breast or thoracic radiation therapy (RT) for any condition
• * Multicentric carcinoma (DCIS or invasive)
• * Synchronous bilateral invasive or non-invasive breast cancer
• * Surgical margins that cannot be microscopically assessed or that are positive
• * Excision cavity that cannot be clearly delineated per the treating investigator
• * Any of the dosimetric treatment criteria defined in Section 6.1 have not been met. Patients who become ineligible due to inability to meet dosimetric criteria should not receive treatment as - defined in this protocol and will come off the study. Any subsequent adjuvant radiation will be delivered at the discretion of the treating physician
• * Medical, psychological, or social condition that, in the opinion of the investigator, may increase the patient's risk or limit the patient's adherence with study requirements