Time-restricted Eating in Peri- and Postmenopausal Women

Eligibility Criteria

• * Healthy women aged 40-58 years
• * Perimenopausal or recently postmenopausal, \>1 year and \<5 years
• * BMI \> 30 kg/m2
• * Dyslipidemic, defined as the presence of one or more lipid-based cardiovascular disease risk-enhancing factors per American College of Cardiology/American Heart Association guidelines
• * Normal renal and hepatic function
• * Perimenopausal women, a negative pregnancy test
• * Diagnosis, or strong clinical suspicion, of eating disorders, including but not limited to, anorexia nervosa, bulimia nervosa, binge eating disorder
• * Concurrent dietary intervention or modification unrelated to study procedures
• * Current major depressive episode
• * Suicidal ideation
• * Lifetime history of bipolar disorder, psychosis, or other serious mental health problem
• * Current alcohol/substance use disorder
• * Use of lipid-lowering or lipid-enhancing medications
• * Use of systemic hormonal (estrogens and/or progestin) therapies
• * Use of weight loss medications or supplements
• * Use of medications that may cause weight loss or gain, unless body weight and medication usage remained stable for at least 6 months
• * Previous weight loss surgery
• * Abnormal vital signs at screening visit
• * Body weight \> 350 pounds, per DXA scan limits
• * Malignancy within past 2 years
• * Major surgery within past 3 months
• * Medical instability considered to interfere with study procedures
• * Contraindications to DXA scanning
• * Use of medications that have the potential to cause hypoglycemia (e.g., insulin, sulfonylureas)
• * Undergoing treatment for cancer
• * Use of medications for which time-restricted eating would interfere with recommended timing of medication ingestion with food intake.
• * Irregular sleep/wake schedule
• * Shiftwork
• * Recent travel across 2 or more time zones
• * Recent change in exercise habits
• * Work or social schedules that would impede ability to adhere to study protocol
• * Initiation of new medications for lipid management, weight loss, hormonal medications, or other medications that may cause changes in weight or lipid levels
• * Development of any significant medical problem
• * Enrollment in another clinical trial involving study procedures or medications that might interfere with study procedures.
• * Significant deviation from study protocol or protocol violation
• * Inability to adhere to time-restricted eating window