Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * 10,000 patients without a known internal (non-cutaneous) cancer or a history of an internal cancer
- * To balance age, rough recruitment goals will be set for the following subsets: 18-39 years, 40-49 years , 50-59 years , 60-69 years , 70-79 years , and \>= 80 years
- * To balance sex, roughly half of the participants recruited within each age subset will be women
- * Roughly half of all participants will have had a colonoscopy or colon x-ray within the past 5 years, or Cologuard® test in the last 3 years which were negative for cancer and precancerous lesions
- * Roughly half of all participants will have had a chest x-ray within the past 5 years which was negative for cancer
- * Roughly half of women participants will have had a mammography in the past 5 years which was negative for cancer
- * An attempt will be made to recruit minimums (parentheses) of the following subsets: men with normal Prostate-specific antigen (PSA) level (200); diabetes mellitus (200); connective tissue diseases like rheumatoid arthritis, systemic lupus erythematosus, and scleroderma (100); chronic obstructive lung disease (100); inflammatory bowel disease or cirrhosis (100), and pancreatitis (100)
- * To assess the effects of other common covariates, specific recruitment targets will not be set. Rather, data obtained on all participants will include BMI, smoking (past/present), alcohol consumption, pregnant status (women), and selected medications (steroidal and non-steroidal anti-inflammatory drugs, statins, anti-hypertensives, and anti-depressants)
- * Patients has a past or current diagnosis of invasive cancer (this does not include basal cell or squamous cell skin cancers)
- * Patient has had a solid organ transplant
- * Inability to give informed consent
- * Patient has transurethral instrumentation (cystoscopy, placement of urinary catheter) within the 7 days prior to sample collection
- * Patient has chronic indwelling urinary catheter
- * Patient has had a urinary tract infection within the 14 days prior to sample collection
- * Patient has known clinically significant xerostomia
- * Patient has known recent (within 30 days prior to collection) active upper respiratory tract infection or anogenital infection
Ages Eligible for Study
18 Years to
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
Yes