RECRUITING

KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

A Study of the Anti-CD 19 Chimeric Antigen Receptor T Cell Therapy for Patients with Myasthenia Gravis

Official Title

KYSA-6: A Phase 2/3, Open-Label, Randomized, Controlled, Multicenter Study of KYV-101, an Autologous Fully Human Anti-CD19 Chimeric Antigen Receptor T-cell (CD19 CAR T) Therapy, Versus Ongoing Standard-Of-Care Immunosuppressive Therapy in Patients With Generalized Myasthenia Gravis

Quick Facts

Study Start:2024-08-28
Study Completion:2028-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06193889

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Kyverna Therapeutics, Inc.
CONTACT
510-925-2484
Clinicaltrials@kyvernatx.com

Principal Investigator

MD
STUDY_DIRECTOR
Kyverna Therapeutics, Inc.

Study Locations (Sites)

University of California, Irvine
Orange, California, 92868
United States
Stanford University Medical Center
Palo Alto, California, 94305
United States
University of Miami
Miami, Florida, 33149
United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
United States
Intermountain Medical Center
Murray, Utah, 84107
United States

Collaborators and Investigators

Sponsor: Kyverna Therapeutics

  • MD, STUDY_DIRECTOR, Kyverna Therapeutics, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-28
Study Completion Date2028-09

Study Record Updates

Study Start Date2024-08-28
Study Completion Date2028-09

Terms related to this study

Keywords Provided by Researchers

  • KYV-101
  • myasthenia gravis
  • autoimmune disease
  • anti-CD19 CAR-T Therapy
  • cellular therapy
  • MG
  • KYSA-6
  • KYV101-006

Additional Relevant MeSH Terms

  • Myasthenia Gravis
  • Generalized Myasthenia Gravis