Improving Status Epilepticus Treatment Times

Description

This is a stepped-wedge cluster randomized effectiveness-implementation hybrid study aimed at determining the effect of dissemination of a QI bundle on the time to treatment of SE among hospitalized, non-critically ill children. The primary study endpoint is to decrease the time from the SE diagnosis to treatment with the first dose of a benzodiazepine (BZD) as measured during hospitalization, which will decrease chances of morbidity and mortality.

Conditions

Status Epilepticus

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Study Overview

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Study Details

Study overview

This is a stepped-wedge cluster randomized effectiveness-implementation hybrid study aimed at determining the effect of dissemination of a QI bundle on the time to treatment of SE among hospitalized, non-critically ill children. The primary study endpoint is to decrease the time from the SE diagnosis to treatment with the first dose of a benzodiazepine (BZD) as measured during hospitalization, which will decrease chances of morbidity and mortality.

Quality Improvement in Time to Treatment of Status Epilepticus

Improving Status Epilepticus Treatment Times

Condition
Status Epilepticus
Intervention / Treatment

-

Contacts and Locations

Columbus

Nationwide Children's Hospital, Columbus, Ohio, United States, 43205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * SE episode occurs in a male or female child aged between \> 30 days to \< 19 years
  • * Seizures meeting AT LEAST ONE of the following criteria:
  • 1. continuous clinically apparent seizure lasting greater than 5 minutes
  • 2. continuous clinically apparent seizure of any duration receiving BZD
  • 3. repeated seizures without return to neurological baseline within 5 minutes
  • * SE episode occurs in a child with infantile spasms
  • * SE episode occurs in a child with electrographic-only seizures without clinical signs other than encephalopathy

Ages Eligible for Study

30 Days to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Nationwide Children's Hospital,

Adam Ostendorf, MD, PRINCIPAL_INVESTIGATOR, Nationwide Children's Hospital and The Ohio State University

Study Record Dates

2027-03-31