Feasibility, Safety and Acceptability of a Mobile Health Delivered Exercise Training Program in Patients With Nonalcoholic Steatohepatitis

Description

This study will be a pilot study to evaluate the feasibility, safety and acceptability of Exercise and Liver FITness (EL-FIT), a mHealth exercise training program previously validated in patients with cirrhosis in patients with nonalcoholic steatohepatitis.

Conditions

NASH - Nonalcoholic Steatohepatitis, NASH, Exercise, Liver

Study Overview

Study Details

Study overview

This study will be a pilot study to evaluate the feasibility, safety and acceptability of Exercise and Liver FITness (EL-FIT), a mHealth exercise training program previously validated in patients with cirrhosis in patients with nonalcoholic steatohepatitis.

Feasibility, Safety and Acceptability of a Mobile Health Delivered Exercise Training Program in Patients With Nonalcoholic Steatohepatitis

Feasibility, Safety and Acceptability of a Mobile Health Delivered Exercise Training Program in Patients With Nonalcoholic Steatohepatitis

Condition
NASH - Nonalcoholic Steatohepatitis
Intervention / Treatment

-

Contacts and Locations

Hershey

Penn State Hershey Medical Center, Hershey, Pennsylvania, United States, 17033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults age \>18 years
  • * Evidence of NASH indicated by at least one of the following
  • * Liver biopsy with evidence of steatohepatitis (NAS \>=4) within 6 months of the screening interval or;
  • * Historical Imaging study (e.g., ultrasound, CT, MRI) with hepatic steatosis and one of the following non-invasive tests within 6 months of the screening interval: i. FIB-4 \>= 1.3 or; ii. NFS \>= -1.44 or; iii. ELF \>= 7.7 or; iv. VCTE kPa \>=8 or; v. ARFI \>=1.3 or; vi. FAST \>= 0.35 or; vii. MRE kPa \>=2.55 or; viii. MAST \> 0.165 or;
  • * Possession of a smartphone
  • * Active cardiac symptoms precluding participation in vigorous exercise
  • * Active or recent participation in exercise training program within the last 90 days
  • * Active or recent weight-loss supplement use within the last 90 days (does not include GLP-1 receptor agonist use)
  • * Active illicit substance use
  • * Cancer that is active
  • * Cirrhosis
  • * Exercise identified to be unsafe by study PI or EL-FIT mHealth program
  • * Inability to provide informed consent
  • * Inability to walk \> 2 blocks
  • * Institutionalized/prisoner
  • * Other chronic liver disease (e.g., viral hepatitis)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Milton S. Hershey Medical Center,

Jonathan G Stine, MD, PRINCIPAL_INVESTIGATOR, Penn State Health

Study Record Dates

2026-03-01