A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

Description

The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.

Conditions

Multiple Sclerosis

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Study Overview

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Study Details

Study overview

The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

Condition
Multiple Sclerosis
Intervention / Treatment

-

Contacts and Locations

East Hanover

Kessler Foundation, East Hanover, New Jersey, United States, 07936

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Be within the ages of 18 and 70 years of age
  • * Speak English as their primary language
  • * Confirmed MS diagnosis by a neurologist
  • * Be relapse and steroid-free for at least 30 days
  • * Moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS)
  • * Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ)
  • * Right handedness
  • * History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)
  • * Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)
  • * Currently use medications that may impact cognition (ex: steroids, benzodiazepines)
  • * Currently pregnant
  • * Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe)
  • * Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Kessler Foundation,

Carly Wender, PhD, PRINCIPAL_INVESTIGATOR, Kessler Foundation

Study Record Dates

2026-06-30