RECRUITING

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

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Conditions

Multiple SclerosisAerobic exerciseVirtual RealityLeg cyclingMobility disability

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.

Official Title

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

Quick Facts

Study Start:2024-02-12
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06197685

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Be within the ages of 18 and 70 years of age
  2. * Speak English as their primary language
  3. * Confirmed MS diagnosis by a neurologist
  4. * Be relapse and steroid-free for at least 30 days
  5. * Moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS)
  6. * Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ)
  7. * Right handedness
  1. * History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)
  2. * Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)
  3. * Currently use medications that may impact cognition (ex: steroids, benzodiazepines)
  4. * Currently pregnant
  5. * Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe)
  6. * Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)

Contacts and Locations

Study Contact

Carly Wender, PhD
CONTACT
(973) 324-8388
cwender@kesslerfoundation.org

Principal Investigator

Carly Wender, PhD
PRINCIPAL_INVESTIGATOR
Kessler Foundation

Study Locations (Sites)

Kessler Foundation
East Hanover, New Jersey, 07936
United States

Collaborators and Investigators

Sponsor: Kessler Foundation

  • Carly Wender, PhD, PRINCIPAL_INVESTIGATOR, Kessler Foundation

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-12
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2024-02-12
Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

  • Multiple Sclerosis
  • Aerobic exercise
  • Virtual Reality
  • Leg cycling
  • Mobility disability

Additional Relevant MeSH Terms

  • Multiple Sclerosis