Induction of Labor in Morbidly Obese Patients

Description

The goal of this randomized control trial is to compare different doses of Misoprostol (25 mcg vs 50 mcg) in induction of labor (IOL) in morbidly obese patients with BMI \>40. It is known that morbid obesity is a risk factor for failed IOL and ultimately cesarean delivery (CD.) If the rates of vaginal delivery in this population can improve, then surgical morbidity can be reduced in these patients.

Conditions

Morbid Obesity, Pregnancy

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Study Overview

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Study Details

Study overview

The goal of this randomized control trial is to compare different doses of Misoprostol (25 mcg vs 50 mcg) in induction of labor (IOL) in morbidly obese patients with BMI \>40. It is known that morbid obesity is a risk factor for failed IOL and ultimately cesarean delivery (CD.) If the rates of vaginal delivery in this population can improve, then surgical morbidity can be reduced in these patients.

Induction of Labor in Morbidly Obese Patients: Comparison of 50 mcg and 25 mcg Misoprostol - A Randomized Control Trial

Induction of Labor in Morbidly Obese Patients

Condition
Morbid Obesity
Intervention / Treatment

-

Contacts and Locations

Baltimore

University of Maryland Medical Center, Baltimore, Maryland, United States, 21201

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Morbidly obese (BMI ≥ 40 kg/m2) at admission for induction of labor
  • * Speaks English or Spanish
  • * Gestational age between 34 weeks and 0 days and 42 weeks and 6 days
  • * Age 18 years old or older
  • * Viable, single, cephalic fetus
  • * Intent to proceed with cervical ripening - cervical exam: dilation \< 5 cm
  • * Contractions \< 5 per 10 minutes
  • * History of cesarean delivery
  • * Contraindication to prostaglandin administration (significant myomectomy, prior cesarean delivery)
  • * Contraindication to vaginal delivery (placenta previa, vasa previa, HIV with high viral load)
  • * Contraindications to labor (cardiac, neurosurgical, need for cesarean)
  • * Age \< 18yo
  • * Fetal growth restriction with abnormal umbilical artery Doppler indices
  • * Cervical dilation \>5 cm
  • * Contractions \>5 per 10 minutes
  • * Significant vaginal bleeding with concern for placental abruption
  • * Non-reassuring fetal status or fetal heart rate decelerations
  • * Fetal demise or major fetal anomaly
  • * Inability to give consent

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Maryland, Baltimore,

Study Record Dates

2025-10