The Effects of Chiropractic in a Population with High Central Adiposity

Description

Since 1980, the global prevalence of obesity, commonly defined as a body mass index (BMI) of 30 or higher, has doubled. Importantly, high levels of central adiposity (i.e., abdominal fat) is associated with numerous PNI-related sequelae, including increased levels of psychological distress, cognitive deficits, ANS dysfunction, and immune marker abnormalities. To our knowledge, rigorous investigation of chiropractic's impact on psychoneuroimmunological (PNI)-related outcomes in people with high central adiposity is lacking. Based on limited evidence to date, it is plausible that clinically important PNI-related dysfunctions (e.g., heightened stress levels, executive function impairments, dysautonomia, immune dysregulation) common in this population could be ameliorated via chiropractic care.

Conditions

Abdominal Obesity

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Study Overview

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Study Details

Study overview

Since 1980, the global prevalence of obesity, commonly defined as a body mass index (BMI) of 30 or higher, has doubled. Importantly, high levels of central adiposity (i.e., abdominal fat) is associated with numerous PNI-related sequelae, including increased levels of psychological distress, cognitive deficits, ANS dysfunction, and immune marker abnormalities. To our knowledge, rigorous investigation of chiropractic's impact on psychoneuroimmunological (PNI)-related outcomes in people with high central adiposity is lacking. Based on limited evidence to date, it is plausible that clinically important PNI-related dysfunctions (e.g., heightened stress levels, executive function impairments, dysautonomia, immune dysregulation) common in this population could be ameliorated via chiropractic care.

Psychoneuroimmunology As a Framework for Studying the Effects of Chiropractic Care in a Population with High Central Adiposity: a Feasibility Trial

The Effects of Chiropractic in a Population with High Central Adiposity

Condition
Abdominal Obesity
Intervention / Treatment

-

Contacts and Locations

Marietta

Dr. Sid E. Williams Center for Chiropractic Research, Marietta, Georgia, United States, 30067

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-65 years of age
  • * Body mass index (BMI) at least 30
  • * Waist circumference at least 35 inches if female or 40 inches if male
  • * Had chiropractic care within the past 30 days
  • * Prescribed short-acting benzodiazepines which include midazolam \& triazolam
  • * If taking prescription medications, other than short-acting benzodiazepines, not on a stable dose for a minimum of 6 weeks with plans to change medications or doses during the study
  • * Not able to walk unassisted on a treadmill
  • * Known disorder resulting in syncope/fainting during postural changes (e.g., POTS, orthostatic hypotension)
  • * Pacemaker or known heart condition that influences the electrical or mechanical function of the heart (e.g., severe heart valve disease)
  • * Diagnosed with externalizing (e.g., substance use, antisocial disorder) or thought (e.g., schizophrenia, paranoid personality, bipolar) disorder that is uncontrolled or untreated
  • * Diagnosed with rheumatoid arthritis, osteoporosis, or cervical spine instability
  • * Hearing impairment (cognitive task uses auditory stimuli)
  • * Currently pregnant
  • * Current litigation related to a physical, health-related injury
  • * Whiplash injury in the past 3 months
  • * Oral injury, inflammation, or disease that causes the mouth or gums to bleed easily

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Life University,

Tyson Perez, DC, PhD, PRINCIPAL_INVESTIGATOR, Life University

Study Record Dates

2025-07-31