Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab

Description

The primary objective of this study is to compare the efficacy of tarlatamab plus durvalumab with durvalumab alone on prolonging overall survival (OS).

Conditions

Extensive-Stage Small-Cell Lung Cancer, Small-Cell Lung Cancer

Study Overview

Study Details

Study overview

The primary objective of this study is to compare the efficacy of tarlatamab plus durvalumab with durvalumab alone on prolonging overall survival (OS).

A Phase 3, Open-label, Multicenter, Randomized Study of Tarlatamab in Combination With Durvalumab vs Durvalumab Alone in Subjects With Extensive-Stage Small-Cell Lung Cancer Following Platinum, Etoposide and Durvalumab (DeLLphi-305)

Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab

Condition
Extensive-Stage Small-Cell Lung Cancer
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of Southern California, Los Angeles, California, United States, 90033

Gainesville

Northeast Georgia Medical Center, Gainesville, Georgia, United States, 30501

Chicago

University of Illinois Chicago, Chicago, Illinois, United States, 60612

Indianapolis

Franciscan Health Indianapolis, Indianapolis, Indiana, United States, 46237

Baton Rouge

Our Lady of the Lake Cancer Institute, Baton Rouge, Louisiana, United States, 70808

Boston

Dana-Farber Cancer Institute, Boston, Massachusetts, United States, 02215

Grand Rapids

Cancer and Hematology Centers of Western Michigan, Grand Rapids, Michigan, United States, 49503

Saint Paul

Allina Health System dba Virginia Piper Cancer Institute, Saint Paul, Minnesota, United States, 55102

Springfield

Oncology Hematology Associates, Springfield, Missouri, United States, 65807

Omaha

Nebraska Cancer Specialists, Omaha, Nebraska, United States, 68130

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to 99 Years

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Amgen,

    MD, STUDY_DIRECTOR, Amgen

    Study Record Dates

    2028-09-25