EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Description

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).

Conditions

Paroxysmal Atrial Fibrillation

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Study Overview

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Study Details

Study overview

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).

EXCLAMATORY: EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation With Exercise CapacitY Longitudinal Study

EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Condition
Paroxysmal Atrial Fibrillation
Intervention / Treatment

-

Contacts and Locations

Richmond

Virginia Commonwealth University, Richmond, Virginia, United States, 23298

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥18 years
  • * Diagnosis of paroxysmal AF
  • * Left ventricular ejection fraction ≥50%
  • * Scheduled for catheter ablation
  • * Able to speak, hear, and read English
  • * Willing and able to provide informed consent
  • * Persistent or permanent AF
  • * Prior ablation (catheter based or surgical) for AF
  • * Significant sinus node dysfunction
  • * Implanted pacemaker or defibrillator
  • * Contraindication to or inability to complete cardiovascular magnetic resonance study
  • * Contraindication to or inability to complete exercise testing
  • * Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2
  • * Severe left ventricular hypertrophy
  • * Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to:
  • * Hypertrophic cardiomyopathy
  • * Cardiac amyloidosis
  • * Constrictive pericarditis
  • * Pulmonary arterial hypertension
  • * Prior cardiac surgery
  • * Active pregnancy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Virginia Commonwealth University,

Cory Trankle, PRINCIPAL_INVESTIGATOR, Virginia Commonwealth University

Study Record Dates

2028-03