Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

Eligibility Criteria

• * All participants must be able to provide a provision of a signed and dated informed consent form.
• * Male or female, aged 22-60 years old Able to provide paperwork from personal primary treating physician that proves stable medical condition with ability to tolerate at least 15 minutes upright
• * Able to self-transfer from the wheelchair and demonstrate active range of motion of bilateral upper extremities in gravity dependent plane
• * Able to passively range bilateral lower extremities within normal mobility parameters including: greater than 90 degrees of hip flexion and 165 degrees of hip extension; greater than 90 degrees of knee flexion and reach neutral knee extension of 180 degrees; neutral ankle position reaching a minimum of 90 degrees of dorsiflexion.
• * Maintain current oral anti-spasticity regimen/dosage as approved by study physician with no change in regular use that may affect study outcomes.
• * 1 to 6 years post spinal cord injury
• * Non-progressive spinal cord injury
• * Chronic motor complete SCI as defined by AIS A or B
• * Neurological level of injury below T2 and above T10 (non-conus injury)
• * Eligible for fMRI per safety questionnaire
• * Women of childbearing potential must agree to the use of an effective means of avoiding pregnancy for the duration of the study.
• * Able to commit to the full study
• * Currently involved in another rehabilitation training study
• * Active pressure sores, unhealed bone fractures, peripheral neuropathies, or painful musculoskeletal dysfunction (including but not limited to contractures in the upper and lower extremities)
• * Any ongoing medical condition which would preclude participant from regular physical activity (including but not limited to: cardiopulmonary disease, uncontrollable autonomic dysreflexia or orthostatic hypotension, active urinary tract infections, pregnant or nursing)
• * Intrathecal baclofen pump therapy for spasticity
• * Must not have received Botox injections to primary lower extremity and trunk musculature within the past 3 months, resulting in absence of muscle tone and precluding response to electrical stimulation therapy
• * Current or history of neuromuscular conditions (including but not limited to: unhealed ligament of muscular tears in the upper or lower extremities, pain in weight bearing positions for upper and lower extremities).
• * Clinically significant depression, psychiatric disorders, or ongoing drug abuse
• * Any reason the PI or treating physician may deem as harmful to the participant to enroll or continue in the study
• * Body Mass Index (BMI) over 30
• * Pregnancy