Response to Acute Exercise in Eating Disorders

Eligibility Criteria

• * Aged 16-25
• * ED participants must meet full criteria for DSM-5 restrictive-spectrum eating disorders characterized by weight and shape concern, I.e., anorexia nervosa (AN); mild, moderate, or in partial remission), atypical AN, and OSFED -AN type only)
• * ED participants must be medically stable, and suitable for outpatient treatment
• * Biological Females, Assigned Female at birth
• * English Speaking
• * Those with a medical condition that precludes exercise (e.g., severe asthma) will be excluded for any contraindications
• * Biological Males, Assigned Male at birth
• * BMI less than 16 (over 18 years) or less than 75% expected body weight (under 18 years)
• * Reported intake on Eating Disorder Examination \<1000kcal daily
• * Current purging \>1x per day
• * Current regular episodes of objective binge eating (\>1x/wk)
• * Current self-report of loss-of control eating per the Eating Disorders Examination Interview
• * ED related hospitalization, partial hospitalization, or residential treatment in the past month
• * Any endorsed medical concerns related to physical activity (as probed in the phone screening questions regarding cardiovascular, pulmonary, or metabolic disease).
• * Major medical disorders (e.g., cancer, AIDS)
• * Physical discomfort or difficulty with blood draws
• * Psychotic disorders
• * Intellectual disabilities
• * Developmental disorders
• * Active substance use disorder
• * Current suicidal risk per the Ask Suicide Screening Questionnaire
• * Pregnancy
• * Psychiatric medications that have not been stable for at least 4 weeks
• * Acute sedatives / pain killers (e.g., benzodiazepines, opioids) and prescription stimulants (e.g., methylphenidate, amphetamines) are not permitted for the full day prior to the laboratory session. The noted short-term medication holds only apply to subjects taking the noted medications in cases used to treat ADHD or other psychiatric conditions
• * Resting heart rate \<50 beats per minute (assessed at screening visit)
• * Low blood pressure (\<90/60), (assessed at screening visit)
• * Daily cannabis use
• * History of light headedness or fainting during blood draws or physical activity
• * History of chest pain during physical activity
• * Bone, joint, cardiac, pulmonary, metabolic, or other medical conditions that may be worsened by physical activity (e.g., COPD, diabetes, hypertension) that are not currently addressed via medication or lifestyle change.
• * Physical disabilities that prohibit task performance (such as blindness or deafness)
• * Any other condition that the investigator believes might put the participant at risk for negative outcomes
• * Individuals with a restrictive eating disorder presentation that does not include weight and shape concern (ARFID) or that has primary binge eating (bulimia nervosa)
• * Indication of health risk associated with exercise on the Physical Activity Readiness Questionnaire