A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)

Description

The main purpose of the study is to understand how safe and tolerable is elranatamab when given along with iberdomide. There are 2 parts to this study. Part 1 will look at how safe and tolerable is elranatamab when given with iberdomide. Part 2 will look at the correct amount of this combination that can be given to patients with relapsed or refractory multiple myeloma. Myeloma is a type of cancer that begins in plasma cells (white blood cells that produce antibodies). Refractory means a disease or condition that does not respond to treatment. Relapsed means the return of a disease after a period of improvement. All study medicines are given in cycles that last 28 days. Everyone taking part in this study will receive elranatamab as a shot under the skin. Iberdomide will be taken by mouth once a day for 21 days over a 28-day cycle. Participants will receive study medicine until: * their disease progresses or, * they experience unacceptable side effects or, * they choose to no longer take part in the study. The study will look at the experiences of people receiving the study medicines. This will help see if the study medicines are safe and can be used for multiple myeloma treatment.

Conditions

Multiple Myeloma

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Study Overview

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Study Details

Study overview

The main purpose of the study is to understand how safe and tolerable is elranatamab when given along with iberdomide. There are 2 parts to this study. Part 1 will look at how safe and tolerable is elranatamab when given with iberdomide. Part 2 will look at the correct amount of this combination that can be given to patients with relapsed or refractory multiple myeloma. Myeloma is a type of cancer that begins in plasma cells (white blood cells that produce antibodies). Refractory means a disease or condition that does not respond to treatment. Relapsed means the return of a disease after a period of improvement. All study medicines are given in cycles that last 28 days. Everyone taking part in this study will receive elranatamab as a shot under the skin. Iberdomide will be taken by mouth once a day for 21 days over a 28-day cycle. Participants will receive study medicine until: * their disease progresses or, * they experience unacceptable side effects or, * they choose to no longer take part in the study. The study will look at the experiences of people receiving the study medicines. This will help see if the study medicines are safe and can be used for multiple myeloma treatment.

A PHASE 1B, OPEN-LABEL STUDY OF ELRANATAMAB IN COMBINATION WITH IBERDOMIDE IN PARTICIPANTS WITH RELAPSED REFRACTORY MULTIPLE MYELOMA

A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)

Condition
Multiple Myeloma
Intervention / Treatment

-

Contacts and Locations

Atlanta

Emory University Hospital Midtown, Atlanta, Georgia, United States, 30308

Atlanta

Emory University Hospital, Atlanta, Georgia, United States, 30322

Atlanta

Winship Cancer Institute, Atlanta, Georgia, United States, 30322

Indianapolis

Indiana CTSI Clinical Research Center (ICRC), Indianapolis, Indiana, United States, 46202

Indianapolis

Indiana University Health University Hospital, Indianapolis, Indiana, United States, 46202

Indianapolis

Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC), Indianapolis, Indiana, United States, 46202

Baltimore

University of Maryland, Baltimore, Maryland, United States, 21201

Worcester

University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, 01655

Omaha

Methodist Hospital, Omaha, Nebraska, United States, 68114

Omaha

Oncology Hematology West P.C. dba Nebraska Cancer - Methodist, Omaha, Nebraska, United States, 68114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Prior diagnosis of multiple myeloma as defined by IMWG criteria
  • * Measurable disease based on IMWG criteria as defined by at least 1 of the following:
  • * Serum M-protein ≥0.5 g/dL by SPEP
  • * Urinary M-protein excretion ≥200 mg/24 hour by UPEP
  • * Serum immunoglobulin FLC ≥10 mg/dL (≥100 mg/L) AND abnormal serum immunoglobulin kappa to lambda FL ratio (\<0.26 or \>1.65)
  • * Part 1: Received 2-4 prior lines of therapy for multiple myeloma, consisting of at least 1 immunomodulatory drug and 1 proteasome inhibitor.
  • * Part 2: Received 1-3 prior lines of therapy for multiple myeloma, consisting of at least 1 immunomodulatory drug and 1 proteasome inhibitor.
  • * ECOG performance status 0-1
  • * Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤1
  • * Plasma cell leukemia, Smoldering multiple myeloma, Waldenström's macroglobulinemia, Amyloidosis, POEMS Syndrome
  • * Impaired cardiovascular function or clinically significant cardiovascular diseases
  • * Stem cell transplant within 12 weeks prior to enrollment or active graft vs host disease
  • * Participants with any active, uncontrolled bacterial, fungal, or viral infection
  • * Any other active malignancy within 3 years prior to enrollment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ
  • * Previous treatment with:
  • * BCMA-directed or CD3 redirecting therapy
  • * Iberdomide (CC-220) or Mezigdomide
  • * Administration of strong inhibitor or inducer of CYP3A4/5 within 2 weeks prior to dosing and during the study
  • * Administration with an investigational product within 30 days preceding the first dose of study intervention
  • * Participant is unable or unwilling to undergo protocol required thromboembolism prophylaxis

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Pfizer,

Pfizer CT.gov Call Center, STUDY_DIRECTOR, Pfizer

Study Record Dates

2028-05-31