RECRUITING

The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans

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Conditions

Post Traumatic Stress DisorderVeteranVery Brief Exposure

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to develop a new behavioral treatment for U.S. combat veterans with post-traumatic stress disorder (PTSD), very brief exposure to combat-related stimuli. The main questions it aims to answer are: 1. How does Very Brief Exposure (combat images and control everyday images) and Visible Exposure to combat stimuli affect brain activity and subjective fear ratings? 2. To what extent are participants aware of the stimuli presented and tolerating the exposures? All participants will view both very brief exposure and visible exposure to combat stimuli in the functional magnetic brain imaging (fMRI) scan. They will provide ratings of fear, awareness, and tolerability. Researchers will compare U.S. combat veterans with PTSD and healthy controls to confirm differences in brain region activation and ratings.

Official Title

The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans

Quick Facts

Study Start:2024-03-22
Study Completion:2026-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06218381

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Males and females ages 18-50
  2. * Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) diagnosis of PTSD
  3. * Traumatic event is a combat-based experience (e.g., being injured, watching a buddy be killed)
  4. * Minimum score of 18 on the Combat Experience Scale (CES)
  5. * Minimum score of 3 or more on Primary Care (PC)-PTSD-5
  6. * Participants with other cooccurring psychiatric disorders (e.g., anxiety, ADHD) will be included to ensure a representative sample.
  1. * Treatment for PTSD, substance abuse, or mental health concerns in the past 6 months
  2. * 10 or more years since the combat trauma
  3. * Acute intoxication
  4. * Severe level of Substance Dependence (6 or more DSM-V symptoms)
  5. * Prior diagnosis of Autistic Spectrum Disorders
  6. * Current or past psychotic disorders or active psychotic symptoms
  7. * Current Bipolar I Disorder
  8. * Dementia
  9. * Neurological or serious medical conditions (e.g., stroke, epilepsy/ seizure disorder, cancer, Lupus, HIV+);
  10. * Traumatic brain injury
  11. * Ferromagnetic implants (e.g., pacemaker), metal braces, retainers, tattoos or permanent make up w/ metallic content, transdermal medicinal patches that cannot be removed
  12. * Neurological or serious medical conditions (e.g., stroke, epilepsy/ seizure disorder, cancer, Lupus, HIV+);
  13. * Lifetime Diagnosis of PTSD, Tourette's Syndrome, Bipolar Disorder, Substance Dependence, Eating Disorder, Autism Spectrum Disorder, a psychotic disorder, Acute Stress Disorder
  14. * Lifetime history of traumatic event defined as a life-threatening event involving physical attack, guns, fire or explosion (i.e the kinds of traumatic events combat veterans are likely to experience)
  15. * Traumatic Brain Injury
  16. * Birth at less than 37 weeks gestational age
  17. * Claustrophobia
  18. * Anxiety Disorder, Mood Disorder, Substance Abuse Disorder, Adjustment Disorder in past 2 years
  19. * Treatment for mental health concern in past 2 years
  20. * Pregnant Females

Contacts and Locations

Study Contact

Courtney Marcelino
CONTACT
323-361-6456
cmarcelino@chla.usc.edu
Bradley S Peterson, MD
CONTACT
323-361-3654
bpeterson@chla.usc.edu

Principal Investigator

Bradley M Peterson, MD
PRINCIPAL_INVESTIGATOR
Children's Hospital Los Angeles

Study Locations (Sites)

Brain Imaging Lab
Los Angeles, California, 90027
United States

Collaborators and Investigators

Sponsor: Children's Hospital Los Angeles

  • Bradley M Peterson, MD, PRINCIPAL_INVESTIGATOR, Children's Hospital Los Angeles

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-22
Study Completion Date2026-01

Study Record Updates

Study Start Date2024-03-22
Study Completion Date2026-01

Terms related to this study

Keywords Provided by Researchers

  • Post Traumatic Stress Disorder
  • Veteran
  • Very Brief Exposure

Additional Relevant MeSH Terms

  • Post Traumatic Stress Disorder