RECRUITING

Short-term And Longer-term Cognitive Impact Of Neurochecks

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI). In current practice, the neurocritical care community performs frequent serial neurological examinations ("neurochecks") in an effort to monitor patients for neurological deterioration following brain injury. Many neurocritical patients are older and/or cognitively fragile, and delirium is common. Although ICU delirium is multifaceted, frequent neurochecks may represent a modifiable risk factor if the investigators can better understand the risks and benefits of various neurocheck frequencies. This project will randomize patients with acute spontaneous intracerebral hemorrhage (ICH) to either hourly (Q1) or every-other-hour (Q2) neurochecks and evaluate the impact of neurocheck frequency on delirium. Second, longer-term cognitive outcomes will be investigated in patients with ICH randomized to Q1 versus Q2 neurochecks with the goal of identifying whether hourly neurochecks increase the risk for dementia.

Official Title

Short-term And Longer-term Cognitive Impact Of Hourly Neurochecks In Acute Brain Injury

Quick Facts

Study Start:2024-07-08
Study Completion:2029-10-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06219889

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. 1. Patients with unstable intracranial bleeding
  2. 2. Patients with known history of intracranial neurological injury
  3. 3. Pre-existing cognitive impairment (known or highly suspected based on family-provided history, Activities of Daily Living Questionnaire)
  4. 4. Pre-existing diagnosed sleep disorder
  5. 5. Comatose or heavily sedated
  6. 6. Death expected within 30 days or other terminal illness
  7. 7. ICH score \>4 (equivalent to mortality risk \>72%)
  8. 8. Pregnancy
  9. 9. Incarcerated
  10. 10. Non-English or non-Spanish speaking

Contacts and Locations

Study Contact

Jamie N LaBuzetta
CONTACT
18582491331
jlabuzetta@ucsd.edu

Study Locations (Sites)

UC San Diego Health
San Diego, California, 92103
United States

Collaborators and Investigators

Sponsor: University of California, San Diego

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-08
Study Completion Date2029-10-31

Study Record Updates

Study Start Date2024-07-08
Study Completion Date2029-10-31

Terms related to this study

Keywords Provided by Researchers

  • neurochecks
  • serial neurological examination
  • delirium

Additional Relevant MeSH Terms

  • Intracerebral Hemorrhage