CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

Description

The purpose of this study is to evaluate pulmonary capillary wedge pressure (PCWP) and other hemodynamic measurements at rest and during exercise in healthy volunteers across the age spectrum.

Conditions

Healthy

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Study Overview

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Study Details

Study overview

The purpose of this study is to evaluate pulmonary capillary wedge pressure (PCWP) and other hemodynamic measurements at rest and during exercise in healthy volunteers across the age spectrum.

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

Condition
Healthy
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Apparently healthy volunteers are eligible to participate in this study if they are free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure.
  • * Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%.
  • * Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment.
  • * Informed consent were obtained.
  • * No history of heart failure.
  • * Willing and able to undergo invasive hemodynamic exercise testing, MRI, and other study assessments.
  • * Clinically significant symptoms of exertional dyspnea or fatigue in daily life in the opinion of the investigators.
  • * Any diagnosis of heart failure
  • * Symptomatic coronary artery disease (e.g., patients with chronic angina)
  • * Symptomatic valvular heart disease
  • * Pulmonary hypertension
  • * Cardiomyopathies
  • * High output heart failure
  • * Pericardial disease
  • * Clinically significant chronic lung disease in the opinion of the investigators
  • * Anemia (hemoglobin \<12 gm/dL in women and \<13 gm/dL in men)
  • * Estimated glomerular filtration rate ≤30mL/min
  • * Pregnant women
  • * Any other disorders or problems that would interfere with the ability to participate safely in the study (e.g. psychiatric disorder or substance abuse)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Barry Borlaug, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2029-01