RECRUITING

SNV1521 in Participants with Advanced Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is testing a new medicine, SNV1521, for people with advanced cancers. The researchers want to find out if SNV1521 is safe, well-tolerated, and effective in treating solid tumors. They are investigating different doses in order to find the most effective and safe one. They are also investigating whether it can be combined with other cancer therapies.

Official Title

A Phase 1, Open-Label Dose Escalation and Expansion Study of SNV1521 in Participants with Advanced Solid Tumors

Quick Facts

Study Start:2024-02-23
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06220864

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Advanced or metastatic solid tumor malignancy
  2. * Evaluable or Measurable disease (RECIST 1.1 Criteria).
  3. * ECOG Performance Status 0 or 1.
  4. * Life expectancy \> 3 months
  1. * History of other malignancy within the past 2 years
  2. * Prior diagnosis of Myelodysplastic syndrome or Acute Myeloid Leukemia
  3. * Significant cardiovascular disease within 6 months
  4. * Significant gastrointestinal disease
  5. * HIV infection with a CD4+ T-cell count \< 200 cells/μL and/or a detectable viral load
  6. * Liver dysfunction

Contacts and Locations

Study Contact

Robert Casper
CONTACT
443-764-9527
rcasper@synnovationtx.com

Study Locations (Sites)

Yale University
New Haven, Connecticut, 06520
United States
Thomas Jefferson University
Philadelphia, Pennsylvania, 19144
United States
Sarah Cannon Research Institute
Nashville, Tennessee, 37203
United States
The University of Texas M.D. Anderson Cancer Center
Houston, Texas, 77030
United States
START Center for Cancer Care
West Valley City, Utah, 84119
United States

Collaborators and Investigators

Sponsor: Synnovation Therapeutics, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-23
Study Completion Date2026-12

Study Record Updates

Study Start Date2024-02-23
Study Completion Date2026-12

Terms related to this study

Additional Relevant MeSH Terms

  • Advanced Solid Tumor