Essential Fats for Enhancing Cognitive Thinking (EFFECT) Study

Description

The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.

Conditions

Cognitive Decline, Cognitive Impairment

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Study Overview

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Study Details

Study overview

The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.

Essential Fats for Enhancing Cognitive Thinking (EFFECT) Study: Dietary Fat Quality and Cognitive Impairment

Essential Fats for Enhancing Cognitive Thinking (EFFECT) Study

Condition
Cognitive Decline
Intervention / Treatment

-

Contacts and Locations

Columbus

The Ohio State University, Columbus, Ohio, United States, 43210

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjective cognitive impairment
  • * BMI ≥30 kg/m2
  • * HbA1C \<6.5%
  • * Diagnosis og cognitive impairment or dementia
  • * Montreal Cognitive Assessment (MoCA) score of \<26
  • * Current or previous diagnosis of Diabetes or use of diabetes medications
  • * Current diagnosis of or current treatment of cancer other than non-melanoma skin cancer
  • * Gastrointestinal diseases or disorders (including pancreatic and gastric bypass surgery) where consumption of the study foods would be contraindication or where the disease or disorder could negatively affect nutrient absorption and/or would prevent participants from tolerating the study foods
  • * Hyperthyroidism diagnosis
  • * Food Allergy or intolerances
  • * Any dietary restriction where consumption of the study foods, study meals/snack or meal challenge or any ingredient would be contraindicated
  • * Use of some oil supplements in the past 4 weeks prior to enrolling
  • * Pregnancy and lactation
  • * Inability to access veins for venipuncture
  • * Antibiotic use in the past month
  • * Psychostimulant or nootropic medication use
  • * Current use of supplements or medications for weight loss or following a weight loss program
  • * Severe or uncontrolled autoimmune diseases
  • * Current or previous diagnosis of severe kidney failure, liver cirrhosis and some pulmonary diseases
  • * Heart disease events (including stroke or heart attack) within last 3 months prior to enrollment
  • * Alcohol or drug abuse

Ages Eligible for Study

40 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Ohio State University,

Martha Belury, PhD, RDN, PRINCIPAL_INVESTIGATOR, Ohio State University

Study Record Dates

2026-05-31