Long COVID-19 [11C]CPPC Study

Eligibility Criteria

• 1. Have the ability to understand the requirements of the study, provide written informed consent, understand and provide written authorization for the use and disclosure of Protected Health Information (PHI) \[per Health Insurance Portability and Accountability Act (HIPAA) Privacy Ruling\] and comply with the study procedures.
• 2. Documented history of COVID infection at least 6 - 12 months before enrollment.
• 3. Men and women at least 18 years old.
• 4. Women must have a negative serum pregnancy test and practice an acceptable method of contraception or be of non-childbearing potential (post-menopausal for at least 2 years or who have undergone hysterectomy, oophorectomy or surgical sterilization).
• 5. Geographic accessibility to the study center and the ability to travel to the clinic for study visits.
• 6. Agrees to the visit schedule as outlined in the informed consent.
• 7. Pre-study labs within normal range, or if abnormal, deemed not clinically significant by the site investigator.
• 1. History of recent nosocomial infection.
• 2. History of chronic neurological disorder, such as epilepsy, or structural Central Nervous System (CNS) abnormality such as stroke or arteriovenous malformation.
• 3. History of head trauma with prolonged loss of consciousness (\>10 minutes) or any neurological condition including stroke, seizure (excluding childhood febrile seizure), or visible structural abnormality on prior MRI.
• 4. Active or recent (in the past year) substance dependence (drugs-including nicotine, marijuana or alcohol).
• 5. Receipt of any investigational drug, device or biologic within 30 days of administration of study compound.
• 6. Use of anti-inflammatory medications, immunosuppressants, or benzodiazepines within 7 days of administration of study compound.
• 7. Any concomitant medical disease or condition limiting the safety to participate including, but not limited to:
• * Coagulopathy
• * Active infection
• 8. Contraindications to MRI scanning to include pacemakers, metallic implants/prosthesis or prohibitive claustrophobia, etc.
• 9. Contraindications to PET scanning to include pregnancy, etc.
• 10. Any medical condition that in the opinion of the study investigators would constitute a safety risk to the subject.
• 11. Any radiation exposure in the past calendar year that in combination with the radiation exposure from this study would exceed 5 rem.
• 12. Any history of learning disability or special education (due to the potential to affect performance on neuropsychological testing).