RECRUITING

Weekly Isotretinoin vs Tetracycline for Moderate Acne

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options. While Isotretinoin, a Vitamin A derivative, is highly effective for severe acne, its side effects limit its use for milder cases. A recent study from our institution investigated a new approach: weekly Isotretinoin dosing. The results were promising, with acne improvement and no major side effects. This suggests that weekly Isotretinoin could be a successful alternative for moderate acne in both males and females. To validate these findings, investigators propose a randomized controlled trial comparing weekly Isotretinoin to daily Doxycycline over four months. This study could confirm the safety and effectiveness of weekly Isotretinoin, as well as shed light on patient satisfaction, and long-term results compared to standard antibiotics. This research may offer a breakthrough in treating moderate acne while addressing concerns about antibiotic overuse.

Official Title

Randomized Controlled Trial of Weekly Oral Isotretinoin vs. Oral Tetracyclines for the Treatment of Moderate Acne Vulgaris

Quick Facts

Study Start:2025-02-01
Study Completion:2026-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06225570

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:12 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. * Patients who are at baseline on long-term Tetracycline antibiotics, long-term Trimethoprim-Sulfamethoxazole, or on Spironolactone for any reason
  2. * Patients who have taken Isotretinoin in the past 6 months
  3. * Patients with hypersensitivity to Isotretinoin or to any of its components
  4. * Females who are pregnant, likely to become pregnant, or will be breast-feeding during the study period
  5. * Patients with a history of major depression, mania, or psychosis with an active episode during the past year including current psychotic symptoms and/or current suicidal ideation
  6. * Adult patients with cognitive impairment
  7. * Patients with baseline kidney or liver disease
  8. * Patients with baseline hypertriglyceridemia
  9. * Patients with history of or current pseudotumor cerebri
  10. * Patients with any clinically significant unstable medical condition which could pose a risk to the safety of the patient
  11. * Inability or unwillingness of subject or legal guardian/representative to give informed consent

Contacts and Locations

Study Contact

Alexandra Richmond
CONTACT
(843) 792-3021
ritteral@musc.edu

Principal Investigator

Penny Huebsch
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29403
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Penny Huebsch, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-01
Study Completion Date2026-05

Study Record Updates

Study Start Date2025-02-01
Study Completion Date2026-05

Terms related to this study

Keywords Provided by Researchers

  • moderate acne vulgaris
  • isotretinoin

Additional Relevant MeSH Terms

  • Acne Vulgaris