Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic

Description

The goal of this study is to test the efficacy of Dupixent in improving post-burn itching symptoms versus the current standard of care.

Conditions

Pruritis

Study Overview

Study Details

Study overview

The goal of this study is to test the efficacy of Dupixent in improving post-burn itching symptoms versus the current standard of care.

A Phase 2 Double-Blind, Randomized, Placebo-Controlled Study to Assess the Efficacy of Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic

Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic

Condition
Pruritis
Intervention / Treatment

-

Contacts and Locations

Akron

Akron Children's Hospital, Akron, Ohio, United States, 44308

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Currently taking Dupixent for any other diagnosis
  • * known allergy to Dupixent
  • * pregnant and or lactating mothers
  • * anyone treated for pruritus using laser therapy
  • * currently receiving adequate relief for pruritis under standard of care medical management by antihistamine or neuroleptic medications
  • * Currently taking steroids
  • * persons with developmental delays or otherwise unable to complete measures
  • * prisoners or anyone otherwise unable to give their own consent or who is not their own guardian
  • * one or more of the following existing disorders: conjunctivitis; any co-existing dermatological condition except burns; any type of cancer; requiring dialysis; chronic Stage 3 or higher kidney disease; biliary disorder; gall bladder disorder; or another renal or hepatic disorder which, in the opinion of study physician, deems this study inappropriate for an eligible individual.
  • * Persons unable to provide their own consent, including prisoners when their incarcerated status is not itself the focus of study, are routinely excluded from clinical trials at this site
  • * We further exclude persons with other dermatological conditions (other than burn) , which may have pruritis or pain associated with them and who may be treated with medications other than Dupixent, and whose perceived benefit could confound our results.
  • * We similarly exclude anyone treated for pruritis by laser therapy as their perceived benefit could confound our results.

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Akron Children's Hospital,

Study Record Dates

2026-12-31