Multimodal Musical Stimulation for Healthy Neurocognitive Aging

Description

This is a Stage I randomized, sham-controlled trial on the effects of multimodal musical stimulation on working memory in aging. Neurologically healthy older and younger adults will be tested on working memory and electroencephalography in the first randomized controlled trial of music as a form of brain stimulation, with multimodal musical stimulation and control stimulation conditions. Results will test the causal role of oscillatory mechanisms of the brain on cognition, and will lay the groundwork to the first musical, neurophysiologically targeted, brain-stimulation device for reversing cognitive decline in aging.

Conditions

Aging

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Study Overview

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Study Details

Study overview

This is a Stage I randomized, sham-controlled trial on the effects of multimodal musical stimulation on working memory in aging. Neurologically healthy older and younger adults will be tested on working memory and electroencephalography in the first randomized controlled trial of music as a form of brain stimulation, with multimodal musical stimulation and control stimulation conditions. Results will test the causal role of oscillatory mechanisms of the brain on cognition, and will lay the groundwork to the first musical, neurophysiologically targeted, brain-stimulation device for reversing cognitive decline in aging.

Multimodal Musical Stimulation for Healthy Neurocognitive Aging

Multimodal Musical Stimulation for Healthy Neurocognitive Aging

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

Boston

Northeastern University, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * normal or corrected-to-normal vision
  • * no more than mild hearing loss
  • * no recent history of neurological or psychiatric disorders, including mood disorders or use of medications that may affect cognition or responsiveness to music.
  • * moderate or severe hearing loss (40+ dB)
  • * visual impairment (including color blindness) that cannot be corrected with glasses or contacts
  • * recently changed dosage of cholinesterase inhibitors or psychotropic medication
  • * recent history of psychotic or schizophrenic episodes
  • * major neurologic diagnosis or other condition that might impair cognition or confound assessments (dementia, ADRD; Parkinson's disease, stroke, brain injury, epilepsy, or recent cardiovascular or neurovascular event)
  • * recent history of serious physical trauma or diagnosis of serious chronic health condition requiring medical treatment and monitoring .

Ages Eligible for Study

18 Years to 95 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Northeastern University,

Psyche Loui, PhD, PRINCIPAL_INVESTIGATOR, Northeastern University

Study Record Dates

2025-12-31