RECRUITING

Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty

Conditions

Knee Replacement Surgery Osteoarthritis, Knee Epidiolex Pain medication

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery. The information collected in this study is necessary to help understand whether CBD may be a useful medication before and/or after surgery. The study hypothesis is that CBD exerts opioid-sparing effects through anti-inflammatory, analgesic, and anxiolytic mechanisms.

Official Title

Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty - a Randomized, Two by Two Factorial, Double-blind, Placebo-controlled Clinical Trial

Quick Facts

Study Start:2024-03-13

Study Completion:2029-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06234631

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Willing and able to read, understand, and sign the informed consent (English) * Willingness to participate in all study measures and restrictions, including patient-reported outcomes and longitudinal follow-up * Scheduled for surgery: primary total knee arthroplasty * Primary diagnosis of osteoarthritis of the surgical knee * Individuals of reproductive potential must agree to use acceptable birth control (defined in manual of operating procedures). This includes currently practicing an effective form of two types of birth control for women of childbearing potential, which are defined as those, alone or in combination, that result in a low failure rate (i.e., less than 1% per year) when used consistently and correctly from the screening visit until 28 days after the last study drug administration. * Participants must also agree not to donate sperm or eggs during study drug administration * Ability to take and to swallow the study medication and be willing to adhere to the treatment regimen * Agreement to adhere to Lifestyle Considerations (see protocol) throughout study duration	* Revision or bilateral total knee arthroplasty * Individuals receiving or actively applying for worker's compensation or disability and other aspects associated with potential secondary gain * Severe physical impairment or clinically significant illness (e.g., blindness, paraplegia) * Co-morbid medical conditions that may significantly impair physical functional status (e.g., current non-skin malignancies, solid organ transplant in the past year) * Illicit drug use (other than cannabis). Unreported opioid use would be exclusionary but reported prescribed opioid use is allowed (e.g. patient denies opioid use but is found to be positive on the urine drug screen) * Use of cannabis products in the past 30 days (self-report and confirmed with urinalysis). Note - may be rescreened with appropriate wash-out period (see protocol) * High daily preoperative opioid dose * Individuals with major neurological disorders, such as dementia, Parkinson's disease, cognitive impairment, epilepsy, history of traumatic brain injury/head injury, and seizures * Individuals with significant illness (e.g., cancer) and/or clinically significant labs (e.g. labs measured by complete blood count (CBC) and basic chemistry with values meaningfully outside of the normal range \[abnormal levels to be reviewed by the Principal Investigator or prescribing provider\]) * Medical or psychiatric conditions that in the judgment of study personnel would preclude participation in this study (e.g., psychosis, suicidal ideation; note that stable anxiety and depression are not exclusions) * Pregnant or nursing women (total joint arthroplasty is typically not indicated in this group of patients) * Self-reported liver cirrhosis * Self-reported uncontrolled diabetes * Self-reported active hepatitis (any etiology, including infectious, autoimmune, or alcohol-related) * Blood pressure at screening above 180 millimeters of mercury (mmHg) systolic and/or 120 mmHg diastolic; if value exceeds the set point, potential participants will have repeat assessment within 5 minutes for up to two additional measurements. * Resting heart rate at screening less than 50 beats per minute (bpm) or greater than 100 bpm; if value exceeds the set point, potential participants will have repeat assessment within 5 minutes for up to two additional measurements. * Elevated liver enzymes and bilirubin (measured by blood test at screening) * Serum total bilirubin ≥ 2.5 milligrams (mg) per deciliter (dL) (mg/dL); or, * Alanine transaminase (ALT) or Alanine transaminase (AST) ≥ 3x upper limit normal (ULN); or, * Alkaline phosphatase ≥ 2x ULN * Severe cardiovascular disease (e.g., current unstable angina, current congestive heart failure, or current severe valvular abnormalities) that is self-reported by patient or in medical record * Current valproate, clobazam, or warfarin use per self-report or medical records * Current use of strong inducers of cytochrome p450 (CYP) enzymes CYP3A4 and CYP2C19, or CYP2C19 substrates with a narrow therapeutic index * Self-reported allergies to sesame oil, strawberries, opioids, or cannabis/cannabinoids * Any impairment, activity, behavior, or situation that in the judgment of the study team would prevent satisfactory completion of the study protocol * Self-reported severe side effects to opioids precluding the use of opioids for post-surgical pain and/or clear plan not to use any opioids after surgery * Participation in other clinical trials over the course of this study

Inclusion Criteria

Exclusion Criteria

* Willing and able to read, understand, and sign the informed consent (English)
* Willingness to participate in all study measures and restrictions, including patient-reported outcomes and longitudinal follow-up
* Scheduled for surgery: primary total knee arthroplasty
* Primary diagnosis of osteoarthritis of the surgical knee
* Individuals of reproductive potential must agree to use acceptable birth control (defined in manual of operating procedures). This includes currently practicing an effective form of two types of birth control for women of childbearing potential, which are defined as those, alone or in combination, that result in a low failure rate (i.e., less than 1% per year) when used consistently and correctly from the screening visit until 28 days after the last study drug administration.
* Participants must also agree not to donate sperm or eggs during study drug administration
* Ability to take and to swallow the study medication and be willing to adhere to the treatment regimen
* Agreement to adhere to Lifestyle Considerations (see protocol) throughout study duration

* Revision or bilateral total knee arthroplasty
* Individuals receiving or actively applying for worker's compensation or disability and other aspects associated with potential secondary gain
* Severe physical impairment or clinically significant illness (e.g., blindness, paraplegia)
* Co-morbid medical conditions that may significantly impair physical functional status (e.g., current non-skin malignancies, solid organ transplant in the past year)
* Illicit drug use (other than cannabis). Unreported opioid use would be exclusionary but reported prescribed opioid use is allowed (e.g. patient denies opioid use but is found to be positive on the urine drug screen)
* Use of cannabis products in the past 30 days (self-report and confirmed with urinalysis). Note - may be rescreened with appropriate wash-out period (see protocol)
* High daily preoperative opioid dose
* Individuals with major neurological disorders, such as dementia, Parkinson's disease, cognitive impairment, epilepsy, history of traumatic brain injury/head injury, and seizures
* Individuals with significant illness (e.g., cancer) and/or clinically significant labs (e.g. labs measured by complete blood count (CBC) and basic chemistry with values meaningfully outside of the normal range \[abnormal levels to be reviewed by the Principal Investigator or prescribing provider\])
* Medical or psychiatric conditions that in the judgment of study personnel would preclude participation in this study (e.g., psychosis, suicidal ideation; note that stable anxiety and depression are not exclusions)
* Pregnant or nursing women (total joint arthroplasty is typically not indicated in this group of patients)
* Self-reported liver cirrhosis
* Self-reported uncontrolled diabetes
* Self-reported active hepatitis (any etiology, including infectious, autoimmune, or alcohol-related)
* Blood pressure at screening above 180 millimeters of mercury (mmHg) systolic and/or 120 mmHg diastolic; if value exceeds the set point, potential participants will have repeat assessment within 5 minutes for up to two additional measurements.
* Resting heart rate at screening less than 50 beats per minute (bpm) or greater than 100 bpm; if value exceeds the set point, potential participants will have repeat assessment within 5 minutes for up to two additional measurements.
* Elevated liver enzymes and bilirubin (measured by blood test at screening)
* Serum total bilirubin ≥ 2.5 milligrams (mg) per deciliter (dL) (mg/dL); or,
* Alanine transaminase (ALT) or Alanine transaminase (AST) ≥ 3x upper limit normal (ULN); or,
* Alkaline phosphatase ≥ 2x ULN
* Severe cardiovascular disease (e.g., current unstable angina, current congestive heart failure, or current severe valvular abnormalities) that is self-reported by patient or in medical record
* Current valproate, clobazam, or warfarin use per self-report or medical records
* Current use of strong inducers of cytochrome p450 (CYP) enzymes CYP3A4 and CYP2C19, or CYP2C19 substrates with a narrow therapeutic index
* Self-reported allergies to sesame oil, strawberries, opioids, or cannabis/cannabinoids
* Any impairment, activity, behavior, or situation that in the judgment of the study team would prevent satisfactory completion of the study protocol
* Self-reported severe side effects to opioids precluding the use of opioids for post-surgical pain and/or clear plan not to use any opioids after surgery
* Participation in other clinical trials over the course of this study

Contacts and Locations

Study Contact

Kendall Dubois

CONTACT

734-232-0324

kendalld@med.umich.edu

Principal Investigator

Chad Brummett, MD

PRINCIPAL_INVESTIGATOR

University of Michigan

Kevin F Boehnke

PRINCIPAL_INVESTIGATOR

University of Michigan

Study Locations (Sites)

University of Michigan

Ann Arbor, Michigan, 48109

United States

Henry Ford Health System

Detroit, Michigan, 48202

United States

Collaborators and Investigators

Sponsor: Chad Brummett

Chad Brummett, MD, PRINCIPAL_INVESTIGATOR, University of Michigan
Kevin F Boehnke, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-13

Study Completion Date2029-01

Study Record Updates

Study Start Date2024-03-13

Study Completion Date2029-01

Terms related to this study

Keywords Provided by Researchers

Epidiolex
Pain medication

Additional Relevant MeSH Terms

Knee Replacement Surgery
Osteoarthritis, Knee