A Study to Evaluate the Safety and Efficacy of Baricitinib in the Treatment of Frontal Fibrosing Alopecia (FFA)

Eligibility Criteria

• * Female at least 18 years of age, and able to provide informed consent
• * Females who are post-menopausal defined, as not have menses for at least 12 months without an alternative medical cause and elevated follicle stimulating hormone in the postmenopausal range as measured during screening
• * Have active FFA that has been diagnosed on or prior to screening visit.
• * Have LPPAI score equal to or greater than 5 at screening.
• * Have evidence of eyebrow loss at baseline
• * Have evidence of hairline recession at baseline
• * Have classic presentation with frontal loss of scalp hair
• * Negative screening for tuberculosis (Quantiferon Gold, T-spot) within 3 months prior to screening or at the screening visit.
• * Agree not to have a live vaccination during the study the exception is herpes zoster vaccine
• * Systemic treatments for FFA within 4 weeks of the baseline visit or 5 half lives whichever one is longer. (ex: finasteride, pioglitazone, hydroxychloroquine, or immunosuppressant medications, such as mycophenolate mofetil).
• * Dutasteride within the last 6 months
• * Have a LPPAI score less than 5 at screening
• * Immunocompromised and with risk factors concerning to investigator for study participation
• * Previous treatment with an oral JAK inhibitor
• * Any condition in the opinion of the investigator which would interfere with the study assessments or procedure
• * Subject is pregnant or breast feeding
• * Surgical intervention including face lifts and micro-blading on the treatment areas
• * Any intervention (facelifts micro blading) that could affect the treatment areas (i.e. scalp and eyebrows)
• * Laser or phototherapy intervention on the treatment areas
• * Have evidence of active TB or latent TB