RECRUITING

Breaking Sitting With High-intensity Interval Training for Brain Health

Conditions

Aging High-intensity interval training Sitting Executive functions Inhibitory control Episodic memory Event-related potentials Functional connectivity

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in cognitively normal older adults. This trial will test the feasibility of HIIT breaks to sitting. It will also address several important but unanswered questions: (1) Does interrupting sitting with short HIIT breaks improve frontoparietal function? (2) Can interrupting sitting with HIIT breaks improve cognitive functions?

Official Title

Breaking Prolonged Sitting With High-intensity Interval Training to Improve Cognitive and Brain Health in Older Adults: A Pilot Feasibility Trial.

Quick Facts

Study Start:2024-02-22

Study Completion:2025-07-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06243016

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years to 75 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Age 60-75 years 2. BMI \<40 kg/m2 3. Sedentary (≥ 6 h/day sitting by a survey question) 4. Not exercising regularly (i.e., not exercising at least three times a week for at least 30 minutes) 5. Capable of exercising vigorously based on the Physical Activity Readiness Questionnaire (PARQ+) 6. Has a medical clearance for maximal exercise and HIIT from a physician 7. Normotensive or participant's blood pressure is controlled 8. Intelligence quotient (IQ) ≥85 9. Fasting plasma glucose \<126 mg/dL 10. Good or corrected vision and hearing 11. Right-handed 12. No significant abnormalities on the ECG during the maximal exercise test 13. No signs and symptoms that suggest an underlying cardiovascular disease as recorded during the maximal exercise test by a study physician. 14. No indications to prematurely stop the maximal exercise test as outlined by the ACSM's Guidelines for Exercise Testing and Prescription	1. Physical disability or musculoskeletal disease prohibitive to vigorous exercise 2. Learning disabilities 3. Cognitive impairment (MoCA \<26) 4. Type 1 or 2 diabetes 5. Neurological condition (e.g., Multiple Sclerosis, Parkinson, Dementia, Mild Cognitive Impairment) 6. Color blindness 7. Brain injury (e.g., traumatic brain injury, stroke, concussion) 8. Migraine headaches 9. Presence of other health conditions that may be exacerbated by exercise 10. History of heart disease 11. High cholesterol not controlled by medication 12. Signs and symptoms indicative of underlying cardiovascular 13. A chronic pulmonary disease 14. Emphysema 15. Pulmonary embolus 16. Asthma 17. History of renal disease 18. History of seizures 19. A neuropsychiatric disorder 20. Osteoporosis if it interferes with an individual's ability to exercise 21. Severe back problems 22. Severe arthritis if it interferes with an individual's ability to exercise 23. Thyroid disorder not controlled by medication 24. Polyneuropathy 25. Sleep disorders 26. Acquired immunodeficiency syndrome (AIDS) 27. Hepatitis C 28. History of long Coronavirus Disease 2019 (COVID-19) 29. History of cancer 30. Current or past smoking \<12 months 31. Corticosteroid intake \< 31 days before screening 32. Opioids taken \< 6 months from screening 33. Anabolic androgens taken \< 31 days before screening 34. A serious illness or hospitalization in the last six months 35. Currently taking medications that can affect the central nervous system (except for anxiolytics) 36. Current participation in an ongoing trial likely to influence exercise ability or cognitive function

Inclusion Criteria

Exclusion Criteria

1. Age 60-75 years
2. BMI \<40 kg/m2
3. Sedentary (≥ 6 h/day sitting by a survey question)
4. Not exercising regularly (i.e., not exercising at least three times a week for at least 30 minutes)
5. Capable of exercising vigorously based on the Physical Activity Readiness Questionnaire (PARQ+)
6. Has a medical clearance for maximal exercise and HIIT from a physician
7. Normotensive or participant's blood pressure is controlled
8. Intelligence quotient (IQ) ≥85
9. Fasting plasma glucose \<126 mg/dL
10. Good or corrected vision and hearing
11. Right-handed
12. No significant abnormalities on the ECG during the maximal exercise test
13. No signs and symptoms that suggest an underlying cardiovascular disease as recorded during the maximal exercise test by a study physician.
14. No indications to prematurely stop the maximal exercise test as outlined by the ACSM's Guidelines for Exercise Testing and Prescription

1. Physical disability or musculoskeletal disease prohibitive to vigorous exercise
2. Learning disabilities
3. Cognitive impairment (MoCA \<26)
4. Type 1 or 2 diabetes
5. Neurological condition (e.g., Multiple Sclerosis, Parkinson, Dementia, Mild Cognitive Impairment)
6. Color blindness
7. Brain injury (e.g., traumatic brain injury, stroke, concussion)
8. Migraine headaches
9. Presence of other health conditions that may be exacerbated by exercise
10. History of heart disease
11. High cholesterol not controlled by medication
12. Signs and symptoms indicative of underlying cardiovascular
13. A chronic pulmonary disease
14. Emphysema
15. Pulmonary embolus
16. Asthma
17. History of renal disease
18. History of seizures
19. A neuropsychiatric disorder
20. Osteoporosis if it interferes with an individual's ability to exercise
21. Severe back problems
22. Severe arthritis if it interferes with an individual's ability to exercise
23. Thyroid disorder not controlled by medication
24. Polyneuropathy
25. Sleep disorders
26. Acquired immunodeficiency syndrome (AIDS)
27. Hepatitis C
28. History of long Coronavirus Disease 2019 (COVID-19)
29. History of cancer
30. Current or past smoking \<12 months
31. Corticosteroid intake \< 31 days before screening
32. Opioids taken \< 6 months from screening
33. Anabolic androgens taken \< 31 days before screening
34. A serious illness or hospitalization in the last six months
35. Currently taking medications that can affect the central nervous system (except for anxiolytics)
36. Current participation in an ongoing trial likely to influence exercise ability or cognitive function

Contacts and Locations

Study Contact

Dominika M Pindus, Ph.D.

CONTACT

217-300-7317

pindus@illinois.edu

Principal Investigator

Dominika M Pindus, Ph.D.

PRINCIPAL_INVESTIGATOR

University of Illinois Urbana-Champaign

Study Locations (Sites)

University of Illinois at Urbana-Champaign

Urbana, Illinois, 61801

United States

Collaborators and Investigators

Sponsor: University of Illinois at Urbana-Champaign

Dominika M Pindus, Ph.D., PRINCIPAL_INVESTIGATOR, University of Illinois Urbana-Champaign

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-22

Study Completion Date2025-07-31

Study Record Updates

Study Start Date2024-02-22

Study Completion Date2025-07-31

Terms related to this study

Keywords Provided by Researchers

High-intensity interval training
Sitting
Executive functions
Inhibitory control
Episodic memory
Event-related potentials
Functional connectivity

Additional Relevant MeSH Terms

Aging