Physiologic Pacing for Symptomatic First-Degree Heart Block

Description

The purpose of this study is to determine if physiologic pacing will improve symptoms and outcomes in patients with symptomatic first-degree heart block (pr interval ≥250ms).

Conditions

Symptomatic First-degree Heart Block

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine if physiologic pacing will improve symptoms and outcomes in patients with symptomatic first-degree heart block (pr interval ≥250ms).

Physiologic Pacing for Symptomatic First-Degree Heart Block

Physiologic Pacing for Symptomatic First-Degree Heart Block

Condition
Symptomatic First-degree Heart Block
Intervention / Treatment

-

Contacts and Locations

Nashville

Ascension Saint Thomas Midtown, Nashville, Tennessee, United States, 37203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged 18 or above
  • * Ventricular Ejection Fraction (EF) \> 50%
  • * New York Heart Association (NYHA) class II-IV
  • * PR interval ≥250ms
  • * Narrow QRS duration (≤140ms) or prolonged QRS duration with typical Right Bundle Branch Block (RBBB) morphology on 12 lead ECG and sinus rhythm
  • * Permanent atrial fibrillation (AF)
  • * Patients who are unable to perform a 6 minute hall walk
  • * Other serious medical condition with life expectancy of less than 1 year
  • * Lack of capacity to consent
  • * Pregnancy
  • * Contraindication to use of the relevant study device or leads (as per current manuals from manufacturer)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Ascension Health,

Study Record Dates

2025-06-30