SW-682 in Advanced Solid Tumors

Description

This is a first-in-human (FIH), Phase 1a/1b open-label, multicenter, dose escalation and dose expansion study of SW-682 in adult participants with metastatic or unresectable advanced solid tumors with or without Hippo pathway alterations that are refractory to, or have progressed, during or after appropriate prior systemic anticancer therapy, including chemotherapy, immunotherapy, radiation therapy or targeted therapy, or for which no treatment is available, or prior standard of care (SOC) therapy was not tolerated and for which there is no further SOC treatment available. The study includes a Part 1 (Phase 1a) dose escalation phase and a Part 2 (Phase 1b) dose expansion to optimize the dose to be used for further development. All participants will self-administer SW-682 by mouth in 28-day cycles.

Conditions

Advanced Solid Tumor, Mesothelioma, Malignant

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Study Overview

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Study Details

Study overview

This is a first-in-human (FIH), Phase 1a/1b open-label, multicenter, dose escalation and dose expansion study of SW-682 in adult participants with metastatic or unresectable advanced solid tumors with or without Hippo pathway alterations that are refractory to, or have progressed, during or after appropriate prior systemic anticancer therapy, including chemotherapy, immunotherapy, radiation therapy or targeted therapy, or for which no treatment is available, or prior standard of care (SOC) therapy was not tolerated and for which there is no further SOC treatment available. The study includes a Part 1 (Phase 1a) dose escalation phase and a Part 2 (Phase 1b) dose expansion to optimize the dose to be used for further development. All participants will self-administer SW-682 by mouth in 28-day cycles.

A Phase 1a/1b Dose Escalation, Dose Expansion Study of SW-682 in Participants With Advanced Solid Tumors Enriched for Those With Hippo Pathway Mutations

SW-682 in Advanced Solid Tumors

Condition
Advanced Solid Tumor
Intervention / Treatment

-

Contacts and Locations

Scottsdale

SpringWorks Clinical Trial Site, Scottsdale, Arizona, United States, 85258

La Jolla

SpringWorks Clinical Trial Site, La Jolla, California, United States, 92037

Los Angeles

USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States, 90033

Los Angeles

SpringWorks Clinical Trial Site, Los Angeles, California, United States, 90095

Cleveland

University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States, 44106

Portland

Knight Cancer Institute Clinical Trials, Portland, Oregon, United States, 97239

Dallas

Mary Crowley Cancer Research, Dallas, Texas, United States, 75230

Houston

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States, 77030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Histologically confirmed, metastatic, or unresectable solid cancer that has either not responded to or progressed during or after appropriate prior systemic anticancer therapy including chemotherapy, immunotherapy, radiation therapy, or appropriate targeted therapy, or for which there is no treatment available or prior SOC therapy was not tolerated and for which there is no further SOC treatment available
  • * Part 1: must have one of the following:
  • * Mesothelioma with or without NF2 mutations
  • * Advanced solid tumors with NF2 mutations
  • * Advanced solid tumors with other Hippo pathway mutations or fusions (e.g., FAT1, LATS1/2, YAP fusions; WWTR1-CAMTA1 in EHE).
  • * Part 2: must have the tumor histology and oncogenic mutation or genomic aberration specific to each dose expansion cohort defined below:
  • * Cohort 1: Participants with mesothelioma with or without NF2 mutations
  • * Cohort 2: Participants with advanced solid tumors with NF2 mutations
  • * Cohort 3: Participants with advanced solid tumors with other Hippo pathway mutations identified during Part 1 (Phase 1a) dose escalation
  • * Cohort 4: SW-682 with appropriate combination therapy.
  • * In both parts, participants should have known oncogenic mutation identified by Next Generation Sequencing or local assay
  • * Must have archival tumor tissue or agree to a fresh tumor biopsy at screening
  • * Measurable disease per RECIST 1.1
  • * Eastern Cooperative Oncology Group (ECOG) performance status of ≤1
  • * Adequate bone marrow, kidney, hepatic, and coagulation function
  • * Evidence of symptomatic CNS metastases, leptomeningeal carcinomatosis, or untreated spinal cord compression
  • * Clinically significant cardiac disease or abnormal cardiac parameters
  • * Preexistence or inheritance of a familial renal syndrome
  • * Concomitant non-anti-arrhythmic medications that are known to prolong the QTc interval
  • * Concomitant medicines that are known strong/moderate inhibitors or inducers of cytochrome P450 3A4 (CYP3A4) and/or CYP1A2 within 14 days or 5 half-lives before the first dose of study treatment
  • * Concomitant medicines that are known sensitive substrates of CYP3A4, CYP2C19, CYP2D6, CYP1A2, and/or CYP2B6 within 14 days or 5 half-lives before the first dose of study treatment
  • * Concomitant medicines that are known sensitive substrates of PGP, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, MATE1, MATE2-K, OCT2
  • * Clinically significant active infection (bacterial, fungal, or viral)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

SpringWorks Therapeutics, Inc.,

Study Record Dates

2030-06