Diet and Depression

Description

This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of UPF.

Conditions

Depression, Major Depressive Disorder, Weight Gain, Obesity, Metabolic Syndrome

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Study Overview

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Study Details

Study overview

This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of UPF.

Assessing the Feasibility and Acceptability of the Reduction of Ultra-processed Foods From the Diets of a Subset of Patients With Depression - A Pilot Open Label Crossover Trial.

Diet and Depression

Condition
Depression
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94107

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-80 year olds (inclusive), all race/ethnic groups
  • * Willing to not change psychotropic medication or psychotherapy regimen during the study
  • * Willing and able to come to UCSF for in person visits two times
  • * Ability to speak and read English and answer participant surveys
  • * Psychiatric hospitalization in past 3 months
  • * Active suicidal ideation with intent and plan or scoring a 3 or higher on the Columbia suicide severity rating scale (C-SSRS)
  • * In a current severe mood state when entering the study that would prohibit compliance with study visits or dietary program
  • * Known GI abnormalities or known GI medical problems (diarrhea, chronic intestinal disease, toxic megacolon, ileum) or known swallowing or chewing disorders or issues
  • * Anticipating or planning any major changes in physical activity or sleep during the study
  • * Pregnant or planning to be pregnant during the study
  • * Breastfeeding or planning to breastfeed during the study

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

D. Nyasha Chagwedera, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Andrew Krystal, MD, MS, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2026-12