A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases

Description

CALiPSO-1 is a Phase 1, multi-centre, dose-confirmation study to evaluate the safety and efficacy of CNTY-101 in participants with refractory B cell-mediated autoimmune diseases including those with moderate to severe systemic lupus erythematosus (SLE) with or without lupus nephritis (LN), idiopathic inflammatory myopathies (IIM), and diffuse cutaneous systemic sclerosis (DcSSc).

Conditions

Systemic Lupus Erythematosus, Lupus Nephritis, Idiopathic Inflammatory Myopathies, Diffuse Cutaneous Systemic Sclerosis

Study Overview

Study Details

Study overview

CALiPSO-1 is a Phase 1, multi-centre, dose-confirmation study to evaluate the safety and efficacy of CNTY-101 in participants with refractory B cell-mediated autoimmune diseases including those with moderate to severe systemic lupus erythematosus (SLE) with or without lupus nephritis (LN), idiopathic inflammatory myopathies (IIM), and diffuse cutaneous systemic sclerosis (DcSSc).

The CALiPSO-1 Study: A Study of CNTY-101, a CD19-targeted CAR iNK Cell Product, in Participants With Refractory B Cell-mediated Autoimmune Diseases

A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases

Condition
Systemic Lupus Erythematosus
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Keck School of Medicine of University of Southern California, Los Angeles, California, United States, 90033

Sacramento

UC Davis, Sacramento, California, United States, 957817

Chicago

Lurie Children's; Northwestern Medicine - Northwestern Medical Group, Chicago, Illinois, United States, 60611

Houston

Texas Children's Hospital, Houston, Texas, United States, 77030

Salt Lake City

Primary Children's Hospital, Salt Lake City, Utah, United States, 84113

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    17 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Century Therapeutics, Inc.,

    Study Record Dates

    2028-08