Function of Tamsulosin in Older Males Undergoing Surgery With Indwelling Catheter

Description

This study is being done to answer the question: What is the impact of a medication called tamsulosin (also called Flomax) on the rate of postoperative urinary retention (POUR) and catheter-associated urinary tract infection (UTI)? One of the most common complications following surgery and associated with Foley catheters is post-operative urinary retention (POUR) after the catheter is removed. This is defined as being unable to urinate spontaneously within 8 hours following the removal of the indwelling Foley catheter (the catheter that sits in your bladder to drain urine after surgery). When this happens, it requires intermittent straight catheterization of the bladder (placing a temporary catheter in the bladder to drain the buildup of urine), which can cause a lot of discomfort and anxiety, as well as increase the risk of catheter-associated urinary tract infection (CAUTI).

Conditions

Postoperative Urinary Tract Infection

Study Overview

Study Details

Study overview

This study is being done to answer the question: What is the impact of a medication called tamsulosin (also called Flomax) on the rate of postoperative urinary retention (POUR) and catheter-associated urinary tract infection (UTI)? One of the most common complications following surgery and associated with Foley catheters is post-operative urinary retention (POUR) after the catheter is removed. This is defined as being unable to urinate spontaneously within 8 hours following the removal of the indwelling Foley catheter (the catheter that sits in your bladder to drain urine after surgery). When this happens, it requires intermittent straight catheterization of the bladder (placing a temporary catheter in the bladder to drain the buildup of urine), which can cause a lot of discomfort and anxiety, as well as increase the risk of catheter-associated urinary tract infection (CAUTI).

Function of Tamsulosin in Older Males Undergoing Surgery With Indwelling Catheter: A Randomized Clinical Trial

Function of Tamsulosin in Older Males Undergoing Surgery With Indwelling Catheter

Condition
Postoperative Urinary Tract Infection
Intervention / Treatment

-

Contacts and Locations

Atlanta

Emory Saint Joseph's Hospital, Atlanta, Georgia, United States, 30308

Atlanta

Emory University Hospital Midtown, Atlanta, Georgia, United States, 30308

Atlanta

Emory University Hospital (EUH), Atlanta, Georgia, United States, 30322

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Planned for elective surgery for any reason (benign, malignant, or indeterminate lesion) with either an open or minimally invasive approach (hepatobiliary, pancreatic, and colorectal operations)
  • * Male and age ≥50 years
  • * Deemed physically fit for surgery
  • * Inability to obtain informed consent
  • * Age \<50 years
  • * Female
  • * Baseline creatinine \>1.5x upper limit of normal
  • * Tamsulosin therapy as a home-medication
  • * Procedure involving the prostate, bladder, ureters, or kidneys
  • * Planned Foley catheter removal on the same day of surgery
  • * Planned nasogastric tube retention on postoperative day 1
  • * Individuals taking daily phosphodiesterase 5 (PDE5) inhibitors (due to the risk of symptomatic hypotension if given with tamsulosin)

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Emory University,

Shishir K Maithel, MD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2026-08