Alcohol After Bariatric Surgery 2

Description

The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\[s\]it aims to answer are: * Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy? * What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy? Participants will participate in two types of alcohol tests (alcohol given orally or administered intravenously) after not eating anything overnight or after having a meal. Researchers will compare men and women who underwent sleeve gastrectomy with men and women who had no surgery, are of similar age and body composition, and have similar alcohol intake patterns.

Conditions

Sleeve Gastrectomy

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Study Overview

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Study Details

Study overview

The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\[s\]it aims to answer are: * Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy? * What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy? Participants will participate in two types of alcohol tests (alcohol given orally or administered intravenously) after not eating anything overnight or after having a meal. Researchers will compare men and women who underwent sleeve gastrectomy with men and women who had no surgery, are of similar age and body composition, and have similar alcohol intake patterns.

Pharmacokinetics and Responses to Alcohol After Bariatric Surgery

Alcohol After Bariatric Surgery 2

Condition
Sleeve Gastrectomy
Intervention / Treatment

-

Contacts and Locations

Urbana

University of Illinois at Urbana Champaign, Urbana, Illinois, United States, 61801

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Surgery groups:
  • * Male and female, 21-64 yrs. of age
  • * Drink at least 1 standard drink per month but no more than 7 per week (women or \> 14 for men)
  • * Underwent SG surgery 1-5 years ago
  • * Male and female who did not undergo bariatric surgery
  • * Age , BMI, race , and alcohol pattern of consumption equivalent to participants in the SG surgery groups
  • * For all groups (surgery and non-surgery groups)
  • * Smoking or having quit smoking less than 2 months ago
  • * Pregnant or breastfeeding
  • * Taking any medications that might affect alcohol metabolism
  • * Anemia
  • * Gastritis, colitis, Crohn's Disease, malabsorptive diseases, inflammatory diseases, liver disease, kidney disease, cancer less than five years ago, stroke, or severe organ dysfunction
  • * Body weight \>450 pounds (because of a limit on body composition machine)
  • * Alcohol use disorder
  • * Regular use of drugs with addiction potential or regular misuse of substances
  • * Abnormality on EKG as determined by a study physician to present a safety risk

Ages Eligible for Study

21 Years to 64 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Illinois at Urbana-Champaign,

Marta Y Pepino de Gruev, PhD, PRINCIPAL_INVESTIGATOR, University of Illinois at Urbana-Champaign

Study Record Dates

2028-08