Modulating Energy Density in Time-Restricted Eating

Description

The goal of this randomized controlled trial is to test the effect of time-restricted eating (14-hour fast, 10-hour eating window) of a low-energy dense diet (reduced calories per gram of food) in older adults with obesity and insulin resistance. The study aims to determine if modulating the energy density of the diet reduces: 1. Insulin resistance and 2. Body weight. Researchers will compare the groups: 1. Following time-restricted eating and given a diet reduced in energy density or 2. Following time-restricted eating and given a diet typically consumed in this population

Conditions

Insulin Resistance, Body Weight

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Study Overview

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Study Details

Study overview

The goal of this randomized controlled trial is to test the effect of time-restricted eating (14-hour fast, 10-hour eating window) of a low-energy dense diet (reduced calories per gram of food) in older adults with obesity and insulin resistance. The study aims to determine if modulating the energy density of the diet reduces: 1. Insulin resistance and 2. Body weight. Researchers will compare the groups: 1. Following time-restricted eating and given a diet reduced in energy density or 2. Following time-restricted eating and given a diet typically consumed in this population

Modulating Energy Density in Time-Restricted Eating

Modulating Energy Density in Time-Restricted Eating

Condition
Insulin Resistance
Intervention / Treatment

-

Contacts and Locations

Baton Rouge

Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States, 70808

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Body mass index (BMI) ≥ 30kg/m2.
  • 2. Mini-Mental State Examination (MMSE) \> 25
  • 3. Geriatric Depression Scale-15 (GDS-15) \< 9
  • 4. Homeostatic model assessment of insulin resistance (HOMA-IR) ≥ 3.
  • 1. Diagnosis of Type 2 diabetes received more than five years ago
  • 2. Diagnosis of type 1 diabetes
  • 3. Evidence of clinically significant renal dysfunction or disease
  • 4. History of malignancy during the past five years
  • 5. Being treated with systemic steroids, olanzapine, or clozapine
  • 6. Being treated with prescription medications for obesity
  • 7. Being treated with thiazolidinediones, glucagon-like-receptor agonists, Dipeptidyl Peptidase IV inhibitors, and insulin
  • 8. Weight change \> 3 kg in the preceding three months
  • 9. Any disease or condition that precludes testing of the study outcomes or makes it unsafe to consume the foods being tested in the study, or subjects are otherwise deemed to be unsuitable for participation in the study (determined by the investigative team)

Ages Eligible for Study

50 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Pennington Biomedical Research Center,

Candida Rebello, PRINCIPAL_INVESTIGATOR, Pennington Biomedical Research Center

Study Record Dates

2025-12