Plasma Rich in Growth Factors in Corneal Endothelial Transplantation

Description

The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss.

Conditions

Fuchs' Endothelial Dystrophy, Corneal Edema

Study Overview

Study Details

Study overview

The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss.

Safety and Efficacy of Brief Intraoperative Corneal Endothelial Graft Incubation in Plasma Rich in Growth Factors (PRGF) for Reducing Postoperative Endothelial Cell Loss

Plasma Rich in Growth Factors in Corneal Endothelial Transplantation

Condition
Fuchs' Endothelial Dystrophy
Intervention / Treatment

-

Contacts and Locations

Miami

Bascom Palmer Eye Institute, Miami, Florida, United States, 33136

Indianapolis

Price Vision Group, Indianapolis, Indiana, United States, 46260

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * undergoing endothelial keratoplasty (DSEK or DMEK) at the Bascom Palmer Eye Institute or Price Vision Group, using corneal graft tissue within 14 days of preservation
  • * History of corneal transplantation in the study eye, Best corrected visual acuity (BCVA) worse than 20/40 in the contralateral eye, systemic immunosuppression, previous intraocular surgical procedures (other than cataract surgery) such as glaucoma tubes or silicone oil.
  • * Adults unable to consent
  • * Pregnant women
  • * Prisoners

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Miami,

Alfonso L Sabater, MD, PRINCIPAL_INVESTIGATOR, Bascom Palmer Eye Institute

Study Record Dates

2026-10-30