RECRUITING

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Nearly 1 million individuals in the United States have multiple sclerosis, which causes fatigue and problems with walking. Fatigue and walking problems are poorly treated, but exercise training, particularly high-intensity walking exercise, may help. This provide insight into whether high-intensity walking exercise can improve fatigue and walking problems in people with multiple sclerosis, which could improve quality of life and reduce economic burden.

Official Title

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Quick Facts

Study Start:2024-03-01
Study Completion:2024-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06264336

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age ≥21 years
  2. * Multiple sclerosis diagnosis
  3. * Stable disease-modifying therapy (DMT) over the past 6 months
  4. * Walking dysfunction (i.e., abnormal gait pattern, Expanded Disability Status Scale (EDSS) score of 4-6.5, and/or Patient-determined disease steps (PDDS) score of 3-6)
  5. * Able to walk for 6 minutes at self-paced speed. Handheld assistive device is acceptable.
  6. * Symptomatic fatigue (Fatigue Severity Score ≥ 4)
  1. * Adults unable to consent
  2. * Pregnant women
  3. * Prisoners
  4. * Multiple sclerosis relapse within the last 30 days
  5. * Other neurological disorders besides multiple sclerosis
  6. * Cardiorespiratory or metabolic diseases (e.g., cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema)
  7. * Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)\<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task.
  8. * Severe osteoporosis
  9. * Failure to pass the graded exercise stress test
  10. * Implanted cardiac pacemaker
  11. * Metal implants in the head or face
  12. * Unexplained, recurring headaches
  13. * History of seizures or epilepsy
  14. * Currently under medication that could increase motor excitability and lower seizure threshold
  15. * Skull abnormalities or fractures
  16. * Concussion within the last 6 months

Contacts and Locations

Study Contact

Brice T Cleland, PhD
CONTACT
312-996-9056
bcleland@uic.edu

Study Locations (Sites)

University of Illinois Chicago
Chicago, Illinois, 60612
United States

Collaborators and Investigators

Sponsor: University of Illinois at Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-01
Study Completion Date2024-12-31

Study Record Updates

Study Start Date2024-03-01
Study Completion Date2024-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Multiple Sclerosis