Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Description

Nearly 1 million individuals in the United States have multiple sclerosis, which causes fatigue and problems with walking. Fatigue and walking problems are poorly treated, but exercise training, particularly high-intensity walking exercise, may help. This provide insight into whether high-intensity walking exercise can improve fatigue and walking problems in people with multiple sclerosis, which could improve quality of life and reduce economic burden.

Conditions

Multiple Sclerosis

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Study Overview

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Study Details

Study overview

Nearly 1 million individuals in the United States have multiple sclerosis, which causes fatigue and problems with walking. Fatigue and walking problems are poorly treated, but exercise training, particularly high-intensity walking exercise, may help. This provide insight into whether high-intensity walking exercise can improve fatigue and walking problems in people with multiple sclerosis, which could improve quality of life and reduce economic burden.

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Condition
Multiple Sclerosis
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Illinois Chicago, Chicago, Illinois, United States, 60612

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥21 years
  • * Multiple sclerosis diagnosis
  • * Stable disease-modifying therapy (DMT) over the past 6 months
  • * Walking dysfunction (i.e., abnormal gait pattern, Expanded Disability Status Scale (EDSS) score of 4-6.5, and/or Patient-determined disease steps (PDDS) score of 3-6)
  • * Able to walk for 6 minutes at self-paced speed. Handheld assistive device is acceptable.
  • * Symptomatic fatigue (Fatigue Severity Score ≥ 4)
  • * Adults unable to consent
  • * Pregnant women
  • * Prisoners
  • * Multiple sclerosis relapse within the last 30 days
  • * Other neurological disorders besides multiple sclerosis
  • * Cardiorespiratory or metabolic diseases (e.g., cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema)
  • * Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)\<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task.
  • * Severe osteoporosis
  • * Failure to pass the graded exercise stress test
  • * Implanted cardiac pacemaker
  • * Metal implants in the head or face
  • * Unexplained, recurring headaches
  • * History of seizures or epilepsy
  • * Currently under medication that could increase motor excitability and lower seizure threshold
  • * Skull abnormalities or fractures
  • * Concussion within the last 6 months

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Illinois at Chicago,

Study Record Dates

2024-12-31