RECRUITING

Cardiometabolic Consequences of the Loss of Ovarian Function

Conditions

Menopause Estrogen Deficiency Aging Adiposity Vascular biology Women's health Women

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease. The purpose of this research is to study how the decrease in estrogen at menopause changes artery health and fat gain, and risk of disease in women as they age. The first aim in this study will determine whether short term and long term low estrogen levels in premenopausal women decreases artery function and whether this is related to an increase in fat in the stomach area. The second aim will determine whether the changes in artery health and body fat are related to changes in a pathway that breaks down an important amino acid called tryptophan. This pathway is thought to play a role in regulating the aging process. Therefore, the investigators will determine whether the decrease in artery health and the increase in body fat in the stomach region with low estrogen is related to changes in this pathway in the blood, in vascular cells and fat tissue. Because estrogen levels fluctuate in premenopausal women, the investigators will use an approach (intervention) that controls estrogen levels to address these aims. The investigators will use a medication that is typically used to treat endometriosis or uterine fibroids to lower estrogen levels and an estrogen patch to increase estrogen in some women. Some women will receive a patch that has no estrogen (called a placebo patch). The intervention period will be 20 weeks. The study will provide us with new knowledge on how low estrogen with menopause affects artery health and fat gain estrogen.

Official Title

Cardiometabolic Consequences of the Loss of Ovarian Function

Quick Facts

Study Start:2024-06-01

Study Completion:2028-08-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06264882

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:20 Years to 45 Years

Sexes Eligible for Study:FEMALE

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Age criteria of 20-45 years: the investigators are determining the effects of ovarian suppression on adiposity and vascular in premenopausal women; * Premenopausal defined as normal menstrual cycle function defined as no more than 1 missed cycle in the previous year: irregular menstrual or missed menstrual cycles could indicate that women are anovulatory and/or perimenopause; * Not pregnant or planning to become pregnant; * Not lactating in the last 3 months; * Serum FSH \<10 IU/L measured during days 1-10 of the menstrual cycle: to ensure the woman is premenopausal and not perimenopausal; * Not on hormonal contraception in the last 3 months; * Sedentary or recreationally active (\<2 days/wk vigorous exercise); * No use of medications that might influence vascular function (i.e., antihypertensives, lipid lowering medications, blood thinners); * No use of antioxidant supplements or chronic NSAIDs or be willing to go off them for 4 weeks prior to enrollment in the study;	* Diabetic or fasted glucose \>126 mg/dL; * Body mass index (BMI) \>35 kg/m2; * Weight change \>5 kg in the last 3 months; * Use of glucocorticoids (inhaled, oral, topical) or drugs that affect glucocorticoid metabolism (e.g., ketoconazole) in the last 3 months; * Excess alcohol consumption, defined as \>14 drinks per week by self-report; * Known hypersensitivity to study medications; * Depressive symptoms, defined as a CES-D score \>16; * Resting blood pressure \>150/90 mmHg; * Preexisting or active cardiac, renal, or hepatic disease: past or current history of these diseases or conditions; * Active or chronic infection: inflammation associated with active or chronic infections impair vascular function; * Thyroid dysfunction, defined as an ultrasensitive TSH \<0.5 or \>5.0 mU/L; volunteers with abnormal TSH values will be reconsidered for participation in the study after follow-up evaluation by the PCP with initiation or adjustment of thyroid hormone replacement; * Smoking or Tobacco use within the previous 12 months; * Severe low bone mass or osteoporosis, defined as a hip or lumbar spine T-score \<-2.0: safety reasons, women who are randomized to the ovarian suppression plus placebo group could see a decrease in bone mineral density due to the suppression of estrogen; * History of venous thromboembolic event (VTE): safety reasons, estradiol therapy can increase the risk of VTE; * History of breast cancer or other estrogen-dependent neoplasm: estradiol therapy is contraindicated;

Inclusion Criteria

Exclusion Criteria

* Age criteria of 20-45 years: the investigators are determining the effects of ovarian suppression on adiposity and vascular in premenopausal women;
* Premenopausal defined as normal menstrual cycle function defined as no more than 1 missed cycle in the previous year: irregular menstrual or missed menstrual cycles could indicate that women are anovulatory and/or perimenopause;
* Not pregnant or planning to become pregnant;
* Not lactating in the last 3 months;
* Serum FSH \<10 IU/L measured during days 1-10 of the menstrual cycle: to ensure the woman is premenopausal and not perimenopausal;
* Not on hormonal contraception in the last 3 months;
* Sedentary or recreationally active (\<2 days/wk vigorous exercise);
* No use of medications that might influence vascular function (i.e., antihypertensives, lipid lowering medications, blood thinners);
* No use of antioxidant supplements or chronic NSAIDs or be willing to go off them for 4 weeks prior to enrollment in the study;

* Diabetic or fasted glucose \>126 mg/dL;
* Body mass index (BMI) \>35 kg/m2;
* Weight change \>5 kg in the last 3 months;
* Use of glucocorticoids (inhaled, oral, topical) or drugs that affect glucocorticoid metabolism (e.g., ketoconazole) in the last 3 months;
* Excess alcohol consumption, defined as \>14 drinks per week by self-report;
* Known hypersensitivity to study medications;
* Depressive symptoms, defined as a CES-D score \>16;
* Resting blood pressure \>150/90 mmHg;
* Preexisting or active cardiac, renal, or hepatic disease: past or current history of these diseases or conditions;
* Active or chronic infection: inflammation associated with active or chronic infections impair vascular function;
* Thyroid dysfunction, defined as an ultrasensitive TSH \<0.5 or \>5.0 mU/L; volunteers with abnormal TSH values will be reconsidered for participation in the study after follow-up evaluation by the PCP with initiation or adjustment of thyroid hormone replacement;
* Smoking or Tobacco use within the previous 12 months;
* Severe low bone mass or osteoporosis, defined as a hip or lumbar spine T-score \<-2.0: safety reasons, women who are randomized to the ovarian suppression plus placebo group could see a decrease in bone mineral density due to the suppression of estrogen;
* History of venous thromboembolic event (VTE): safety reasons, estradiol therapy can increase the risk of VTE;
* History of breast cancer or other estrogen-dependent neoplasm: estradiol therapy is contraindicated;

Contacts and Locations

Study Contact

Kerrie Moreau, PhD

CONTACT

303-724-1914

kerrie.moreau@cuanschutz.edu

Claire Cox, BA

CONTACT

303-724-1396

claire.cox@cuanschutz.edu

Principal Investigator

Kerrie Moreau, PhD

PRINCIPAL_INVESTIGATOR

University of Colorado Denver Anschutz Medical Campus

Study Locations (Sites)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045

United States

Collaborators and Investigators

Sponsor: University of Colorado, Denver

Kerrie Moreau, PhD, PRINCIPAL_INVESTIGATOR, University of Colorado Denver Anschutz Medical Campus

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-01

Study Completion Date2028-08-31

Study Record Updates

Study Start Date2024-06-01

Study Completion Date2028-08-31

Terms related to this study

Keywords Provided by Researchers

Vascular biology
Women's health
Women

Additional Relevant MeSH Terms

Menopause
Estrogen Deficiency
Aging
Adiposity