Study to Evaluate the Recombinant Vesicular Stomatitis Virus (rVSV)-Marburg Virus Vaccine Candidate (PHV01) in Healthy Adult Subjects

Description

This is a Phase 1 randomized, single-blind, placebo-controlled, ascending dose study to evaluate the safety and immunogenicity of rVSV∆G-MARV-GP \[Angola\] (PHV01, Marburg Virus glycoprotein \[MARV GP\] Vaccine) in healthy adults. PHV01 is a live, attenuated rVSV vaccine expressing the MARV GP. The main questions it aims to answer are: * Which dose of PHV01 is safe to administer to, and well-tolerated by healthy adult subjects? * What is the immunologic response (Marburg-specific Immunoglobulin G (IgG) ELISA antibody and neutralizing antibodies) to each dose level? Participants will receive 1 intramuscular injection of PHV01 or placebo on Day 1 and will be followed for 181 days.

Conditions

Marburg Virus Disease

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Study Overview

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Study Details

Study overview

This is a Phase 1 randomized, single-blind, placebo-controlled, ascending dose study to evaluate the safety and immunogenicity of rVSV∆G-MARV-GP \[Angola\] (PHV01, Marburg Virus glycoprotein \[MARV GP\] Vaccine) in healthy adults. PHV01 is a live, attenuated rVSV vaccine expressing the MARV GP. The main questions it aims to answer are: * Which dose of PHV01 is safe to administer to, and well-tolerated by healthy adult subjects? * What is the immunologic response (Marburg-specific Immunoglobulin G (IgG) ELISA antibody and neutralizing antibodies) to each dose level? Participants will receive 1 intramuscular injection of PHV01 or placebo on Day 1 and will be followed for 181 days.

A Phase 1 Randomized, Single-Blind, Placebo-Controlled, Ascending Dose Study to Evaluate the Safety and Immunogenicity of rVSV∆G-MARV-GP [Angola] (PHV01, MARV GP Vaccine) in Healthy Adults

Study to Evaluate the Recombinant Vesicular Stomatitis Virus (rVSV)-Marburg Virus Vaccine Candidate (PHV01) in Healthy Adult Subjects

Condition
Marburg Virus Disease
Intervention / Treatment

-

Contacts and Locations

Hollywood

CenExel RCA, Hollywood, Florida, United States, 33024

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy, adult, male or non-pregnant, non-lactating females, age 18-60 years
  • * Given written informed consent
  • * No clinically significant health problems
  • * Negative test for SARS-CoV-2
  • * Agree to avoid conception through Day 29
  • * Agree to minimize blood and body fluid exposures to others after vaccination through Day 29
  • * Agree to avoid exposure to immunocompromised persons after vaccination through Day 29
  • * Prior infection with Marburg virus, related filovirus, or Ebola virus
  • * Prior infection with vesicular stomatitis virus (VSV)
  • * Received any VSV-vectored vaccine
  • * BMI of ≥ 35
  • * Household contact who is immunodeficient, or on immunosuppressive medication
  • * Hepatitis B, hepatitis C, HIV-1, HIV-2, history of long COVID, diabetes, atopic dermatitis (eczema), chronic inflammatory disease, autoimmune or autoinflammatory disorder, malignancy, chronic or active neurologic disorder
  • * History of severe reactions to any vaccine or history of severe allergies
  • * Receipt of investigational product up to 30 days prior to randomization
  • * Receipt of licensed or authorized non-live vaccines within 14 days of planned study immunization (30 days for live vaccines).
  • * Known allergy to components of PHV01
  • * Injection sites obscured by tattoos or physical condition
  • * Significant psychiatric or medical condition or laboratory abnormality on screening
  • * History of Guillain Barre Syndrome or any chronic or acute neurological disorder
  • * Alcohol or illicit drug abuse within past 5 years
  • * Pregnant or lactating female
  • * Administration of blood or IgG within 60 days preceding study
  • * Administration of systemic chronic immunosuppressants (defined as more than 14 days) or other immune modifying drugs within 6 months of study entry
  • * History of blood donation within 60 days of study
  • * Unwilling to undergo diagnostic evaluation of rash (skin biopsy, if indicated) or joint symptoms (arthrocentesis if indicated by joint effusion), in both cases if acceptable to subject
  • * Elective surgery planned during the study period

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Public Health Vaccines LLC,

Joan Fusco, PhD, STUDY_CHAIR, Public Health Vaccines

Richard Kenney, MD, STUDY_DIRECTOR, Public Health Vaccines

Study Record Dates

2024-09-16